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Invitrogen
Claudin 7 Polyclonal Antibody
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FIGURE: 1 / 1
Claudin 7 Antibody (PA5-96042) in WB
Western blot analysis of Claudin 7 in extracts of various cell lines. Samples were incubated with Claudin 7 Polyclonal antibody (Product # PA5-96042) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 30s.
Product Details
PA5-96042
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 29-211 of human CLDN7 (NP_0012983)
Conjugate
Form
Liquid
Concentration
0.73 mg/mL
Amount
73 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: QWQMSSYAGD NIITAQAMYK GLWMDCVTQS TGMMSCKMYD SVLALSAALQ ATRALMVVSL VLGFLAMFVA TMGMKCTRCG GDDKVKKARI AMGGGIIFIV AGLAALVACS WYGHQIVTDF YNPLIPTNIK YEFGPAIFIG WAGSALVILG GALLSCSCPG NESKAGYRVP RSYPKSNSSK EYV; Positive Samples: MCF7, HT-29, A-549, HO-8910PM, Mouse lung, Mouse kidney, Mouse liver, rat kidney, rat liver; Cellular Location: Cell junction, Cell membrane, Lateral cell membrane, Multi-pass membrane protein, tight junction
Target Information
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. Differential expression of this gene has been observed in different types of malignancies, including breast cancer, ovarian cancer, hepatocellular carcinomas, urinary tumors, prostate cancer, lung cancer, head and neck cancers, thyroid carcinomas, etc. Alternatively spliced transcript variants encoding different isoforms have been found.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Claudin-7; CLDN-7; clostridium perfringens enterotoxin receptor-like 2; epididymis secretory sperm binding protein; unnamed protein product
Gene Aliases: CEPTRL2; claudin-1; CLDN-7; CLDN7; CPETRL2; Hs.84359
UniProt ID: (Human) O95471, (Rat) Q9Z1L1, (Mouse) Q9Z261
Entrez Gene ID: (Human) 1366, (Rat) 65132, (Mouse) 53624
cell adhesion
calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules
bicellular tight junction assembly
negative regulation of cell adhesion
positive regulation of cell proliferation
negative regulation of protein homooligomerization
negative regulation of apoptotic process
positive regulation of cell motility
positive regulation of defense response to virus by host
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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