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Clusterin alpha Polyclonal Antibody

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View all (4) Clusterin Alpha antibodies

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Clusterin alpha Polyclonal Antibody

Product Details

OSC00284W-100UL

Applications
Tested Dilution
Publications

Western Blot (WB)

1:200-1:2,000
-

Immunohistochemistry (IHC)

1:200-1:2,000
-

Miscellaneous PubMed (Misc)

-
View 2 publications 2 publications
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / Ig

Class

Polyclonal

Type

Antibody

Immunogen

A synthetic peptide from aa region 300-350 of human Clusterin conjugated to an immunogenic carrier protein was used as the antigen
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

Conc. Not Determined

Storage buffer

whole serum

Contains

no preservative

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.

Specificity of this antibody: Clusterin alpha chain.

Target Information

Isoform 1 of Clusterin prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosomal or proteasomal degradation. Intracellular isoforms interact with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes and promote the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes proteasomal degradation of COMMD1 and IKBKB. Modulates NF-kappa-B transcriptional activity. Nuclear isoforms promote apoptosis. Mitochondrial isoforms suppress BAX-dependent release of cytochrome c into the cytoplasm and inhibit apoptosis. Plays a role in the regulation of cell proliferation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: Aging-associated gene 4 protein; aging-associated protein 4; Apo-J; Apolipoprotein J; apolipoprotein J precursor; CLI; Clusterin; Complement cytolysis inhibitor; complement cytolysis inhibitor precursor; complement lysis inhibitor; Complement-associated protein SP-40,40; epididymis secretory sperm binding protein; Ku70-binding protein 1; NA1/NA2; SGP-2; Sulfated glycoprotein 2; Testosterone-repressed prostate message 2; TRPM-2; unnamed protein product

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Gene Aliases: AAG4; APO-J; APOJ; CLI; CLU; CLU1; CLU2; KUB1; NA1/NA2; SGP-2; SGP2; SP-40; TRPM-2; TRPM2

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UniProt ID: (Human) P10909

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Entrez Gene ID: (Human) 1191

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Function(s)
beta-amyloid binding receptor binding protein binding ATPase activity ubiquitin protein ligase binding macromolecular complex binding protein heterodimerization activity receptor agonist activity tau protein binding low-density lipoprotein particle receptor binding unfolded protein binding chaperone binding misfolded protein binding protein sequestering activity protein carrier chaperone
Process(es)
cell morphogenesis microglial cell activation release of cytochrome c from mitochondria negative regulation of activation of membrane attack complex immune system process immune complex clearance protein folding lipid metabolic process apoptotic process complement activation complement activation, classical pathway response to virus positive regulation of gene expression protein import negative regulation of protein complex assembly positive regulation of protein complex assembly central nervous system myelin maintenance positive regulation of proteasomal ubiquitin-dependent protein catabolic process positive regulation of tumor necrosis factor production regulation of cell proliferation regulation of apoptotic process positive regulation of apoptotic process negative regulation of neuron apoptotic process reverse cholesterol transport innate immune response positive regulation of nitric oxide biosynthetic process negative regulation of complement activation positive regulation of receptor-mediated endocytosis protein stabilization positive regulation of NF-kappaB transcription factor activity chaperone-mediated protein complex assembly response to misfolded protein microglial cell proliferation protein targeting to lysosome involved in chaperone-mediated autophagy negative regulation of release of cytochrome c from mitochondria intrinsic apoptotic signaling pathway beta-amyloid clearance regulation of beta-amyloid clearance positive regulation of beta-amyloid formation negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage negative regulation of beta-amyloid formation regulation of neuronal signal transduction positive regulation of neurofibrillary tangle assembly negative regulation of response to endoplasmic reticulum stress negative regulation of complement-dependent cytotoxicity negative regulation of amyloid fibril formation positive regulation of amyloid fibril formation positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process positive regulation of intrinsic apoptotic signaling pathway
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