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Clusterin alpha Polyclonal Antibody
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Product Details
OSC00286W-100UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse,
Rat
Host/Isotype
Rabbit
/ Ig
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide from aa region 400-448 of mouse Clusterin conjugated to an immunogenic carrier protein was used as the antigen
Conjugate
Form
Lyophilized
Concentration
Conc. Not Determined
Storage buffer
whole serum
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Specificity of this antibody: Clusterin alpha chain.
Target Information
Isoform 1 of Clusterin prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosomal or proteasomal degradation. Intracellular isoforms interact with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes and promote the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes proteasomal degradation of COMMD1 and IKBKB. Modulates NF-kappa-B transcriptional activity. Nuclear isoforms promote apoptosis. Mitochondrial isoforms suppress BAX-dependent release of cytochrome c into the cytoplasm and inhibit apoptosis. Plays a role in the regulation of cell proliferation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Apo-J; Apolipoprotein J; Clusterin; Clustrin; complement lysis inhibitor; DAG; Dimeric acid glycoprotein; SGP-2; Sulfated glycoprotein 2; testosterone repressed prostate message; Testosterone repressed prostate message 2; testosterone repressed prostate message-2; testosterone-repressed prostate message; testostrone-repressed prostate message 2; TRPM-2
Gene Aliases: AI893575; APOJ; CLI; Clu; D14Ucla3; DAG; Msgp-2; RATTRPM2B; SGP-2; SGP2; SP-40; SP40; Sugp-2; TRPM-2; Trpm2; TRPM2B; Trpmb
UniProt ID: (Rat) P05371, (Mouse) Q06890
Entrez Gene ID: (Rat) 24854, (Mouse) 12759
cell morphogenesis
microglial cell activation
response to oxidative stress
spermatogenesis
aging
positive regulation of cell proliferation
response to light stimulus
response to wounding
response to virus
protein import
endocrine pancreas development
central nervous system myelin maintenance
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
negative regulation of protein homooligomerization
positive regulation of tumor necrosis factor production
response to potassium ion
positive regulation of apoptotic process
negative regulation of apoptotic process
estrous cycle
positive regulation of nitric oxide biosynthetic process
positive regulation of cell differentiation
neuron projection morphogenesis
protein stabilization
positive regulation of NF-kappaB transcription factor activity
chaperone-mediated protein complex assembly
response to misfolded protein
chaperone-mediated protein folding
microglial cell proliferation
cellular response to growth factor stimulus
intrinsic apoptotic signaling pathway
regulation of beta-amyloid clearance
regulation of neuron death
positive regulation of neuron death
positive regulation of beta-amyloid formation
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
negative regulation of beta-amyloid formation
regulation of neuronal signal transduction
positive regulation of tau-protein kinase activity
positive regulation of neurofibrillary tangle assembly
positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
positive regulation of intrinsic apoptotic signaling pathway
cell death
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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