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MUbio
Collagen IV Polyclonal Antibody
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Product Details
MUB0338S
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bovine,
Human,
Pig,
Rat
Host/Isotype
Rabbit
/ Ig
Class
Polyclonal
Type
Antibody
Immunogen
Collagen IV
Conjugate
Form
Liquid
Storage buffer
whole serum
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
For immunohistochemistry on paraffin tissue the sections should be pretreated with 1 mg/mL pepsin in 0.01 N HCl for 30 minutes at room temperature.
The antibody may be stored at 4°C. For prolonged storage prepare appropriate aliquots and store at or below -20°C. Prior to use, an aliquot is thawed slowly in the dark at ambient temperature, spun down again and used to prepare working dilutions by adding sterile phosphate buffered saline (PBS, pH 7.2). Repeated thawing and freezing should be avoided. Working dilutions should be stored at 4°C, not refrozen, and preferably used the same day. If a slight precipitation occurs upon storage, this should be removed by centrifugation. It will not affect the performance or the concentration of the product.
Target Information
Collagen IV is a type of collagen protein that is a major component of the basement membrane in various tissues, including the kidneys, lungs, and skin. It forms a network-like structure that provides support and stability to the surrounding tissue. Collagen IV is composed of three alpha chains, which are encoded by the COL4A1, COL4A2, and COL4A3 genes. Mutations in these genes can lead to various genetic disorders, such as Alport syndrome and Goodpasture syndrome, which affect the kidneys and lungs, respectively.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: a matrix-derived inhibitor of angiogenesis and tumor growth; a3(IV)NC1; alpha 1 type IV collagen; alpha-2 collagen type IV; alpha-3 type IV collagen; arresten; canstatin; COL4A1 NC1 domain; COL4A2 NC1 domain; COL4A3 NC1 domain; Collagen 4; Collagen alpha-1(IV) chain; collagen alpha-2 type IV; Collagen alpha-2(IV) chain; Collagen alpha-3(IV) chain; Collagen alpha-4(IV) chain; Collagen alpha-5(IV) chain; Collagen alpha-6(IV) chain; collagen IV, alpha-1 polypeptide; collagen IV, alpha-3 polypeptide; Collagen IV, alpha-4 polypeptide; collagen IV, alpha-5 polypeptide; collagen IV, alpha-6 polypeptide; collagen of basement membrane, alpha-1 chain; collagen of basement membrane, alpha-4 chain; collagen of basement membrane, alpha-5 chain; collagen of basement membrane, alpha-6; collagen type IV alpha 5 chain; collagen, type IV, alpha 1; collagen, type IV, alpha 2; collagen, type IV, alpha 3 (Goodpasture antigen); collagen, type IV, alpha 4; collagen, type IV, alpha 5; collagen, type IV, alpha 6; contains COL4A1 NC1 domain; dA149D17.3; dA24A23.1; dJ889N15.4 (Collagen Alpha 6(IV)); Goodpasture antigen; matrix-derived inhibitor of angiogenesis and tumor growth; non-collagenous 1 domain from alpha 1 chain of type IV collagen; pro-alpha-1(IV); procollagen alpha-1 type IV; procollagen, type IV, alpha 1; procollagen, type IV, alpha 2; procollagen, type IV, alpha 3; procollagen, type IV, alpha 4; procollagen, type IV, alpha 5; soluble Col4A1 protein; structural non-collagenous NC1 domain; a6[IV]NC1; tumstatin; Type IV Collagen; unnamed protein product
Gene Aliases: ASLN; ATS; ATS1; ATS2; ATS3; ATS3A; ATS3B; BFH; BFH1; BFH2; BSVD; BSVD1; BSVD2; CA44; CA54; COL4A1; COL4A1s; COL4A2; COL4A3; COL4A4; COL4A5; COL4A6; CXDELq22.3; DELXq22.3; DFNX6; ICH; PADMAL; POREN2; RATOR; RGD1565499
UniProt ID: (Bovine) Q7SIB2, (Human) P02462, (Human) P08572, (Human) Q01955, (Human) P53420, (Human) P29400, (Human) Q14031
Entrez Gene ID: (Pig) 100515336, (Bovine) 282191, (Human) 1282, (Pig) 100153454, (Human) 1284, (Bovine) 317711, (Pig) 100621504, (Human) 1285, (Bovine) 407107, (Pig) 100621403, (Human) 1286, (Human) 1287, (Pig) 100737091, (Human) 1288, (Pig) 100620724, (Rat) 290905, (Rat) 306628, (Rat) 363265, (Rat) 301562, (Rat) 363457, (Rat) 363458
extracellular matrix structural constituent conferring tensile strength
platelet-derived growth factor binding
extracellular matrix structural constituent
protein binding
binding, bridging
integrin binding
structural molecule activity
metalloendopeptidase inhibitor activity
molecular_function
extracellular matrix structural protein
extracellular matrix protein
patterning of blood vessels
brain development
neuromuscular junction development
collagen-activated tyrosine kinase receptor signaling pathway
retinal blood vessel morphogenesis
renal tubule morphogenesis
cellular response to amino acid stimulus
basement membrane organization
angiogenesis
epithelial cell differentiation
blood vessel morphogenesis
transcription, DNA-templated
response to activity
negative regulation of angiogenesis
extracellular matrix organization
endodermal cell differentiation
cellular response to transforming growth factor beta stimulus
cell adhesion
cell surface receptor signaling pathway
sensory perception of sound
negative regulation of cell proliferation
glomerular basement membrane development
endothelial cell apoptotic process
negative regulation of vascular endothelial cell proliferation
activation of cysteine-type endopeptidase activity involved in apoptotic process
cell proliferation
response to glucose
biological_process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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