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Collagen Type I Polyclonal Antibody

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Collagen Type I Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded human breast cancer tissue slide using 14695-1-AP (Collagen Type I antibody) at dilution of 1:1000 (under 40x lens) heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

Collagen Type I Antibody in Western Blot (WB) — Human kidney tissue were subjected to SDS PAGE followed by western blot with 14695-1-AP (Collagen Type I antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours.

Product Details

14695-1-AP

Applications	Tested Dilution	Publications
Western Blot (WB)	1:1,000-1:4,000	View 75 publications 75 publications
Immunohistochemistry (IHC)	-	View 15 publications 15 publications
Immunocytochemistry (ICC/IF)	-	View 12 publications 12 publications
Miscellaneous PubMed (Misc)	-	View 6 publications 6 publications

Product Specifications
Species Reactivity	Human, Mouse, Pig, Rat
Published species	Dog, Human, Mouse, Pig, Rabbit, Rat
Host/Isotype	Rabbit / IgG
Class	Polyclonal
Type	Antibody
Immunogen	Collagen Type I Fusion Protein Ag6281 (1017-1366 aa encoded by BC054498) View immunogen
Conjugate	Unconjugated
Form	Liquid
Concentration	0.32 mg/mL
Purification	Antigen affinity chromatography
Storage buffer	PBS, pH 7.3, with 50% glycerol
Contains	0.02% sodium azide
Storage conditions	-20°C

Product Specific Information

Immunogen sequence: RGLPGLKGH NGLQGLPGIA GHHGDQGAPG SVGPAGPRGP AGPSGPAGKD GRTGHPGTVG PAGIRGPQGH QGPAGPPGPP GPPGPPGVSG GGYDFGYDGD FYRADQPRSA PSLRPKDYEV DATLKSLNNQ IETLLTPEGS RKNPARTCRD LRLSHPEWSS GYYWIDPNQG CTMDAIKVYC DFSTGETCIR AQPENIPAKN WYRSSKDKKH VWLGETINAG SQFEYNVEGV TSKEMATQLA FMRLLANYAS QNITYHCKNS IAYMDEETGN LKKAVILQGS NDVELVAEGN SRFTYTVLVD GCSKKTNEWG KTIIEYKTNK PSRLPFLDIA PLDIGGADQE FFVDIGPVCF K (1017-1366 aa encoded by BC054498)

Target Information

Collagen I is a Type I collagen with a triple helix structure comprised of two alpha-1 chains and one alpha-2 chain. Collagen I is a member of group I collagen (fibril-forming collagen) found in most connective tissues, and is abundant in bone, cornea, dermis and tendon. Mutations in the COL1A2 gene encoding the alpha-2 chain are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIB, recessive Ehlers-Danlos syndrome Classical type, idiopathic osteoporosis, and atypical Marfan syndrome. Symptoms associated with mutations in the COL1A2 gene which codes for the alpha-2 chain, however, tend to be less severe than mutations in the COL1A1 gene, reflecting the different role of alpha-2 chains in matrix integrity. Reciprocal translocations between chromosomes 17 and 22, where Collagen Type 1 genes and the gene for platelet derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Zhang B,Jiang J,Yue Z,Liu S,Ma Y,Yu N,Gao Y,Sun S,Chen S,Liu P

Tue Nov 01 00:00:00 EDT 2016

MAD2B promotes tubular epithelial-to-mesenchymal transition and renal tubulointerstitial fibrosis via Skp2.

Journal of molecular medicine (Berlin, Germany)

Tang H,Fan D,Lei CT,Ye C,Gao P,Chen S,Meng XF,Su H,Zhang C

Tue Nov 01 00:00:00 EDT 2016

Tetramethylpyrazine Attenuates Transdifferentiation of TGF-β2-Treated Human Tenon's Fibroblasts.

Investigative ophthalmology & visual science

Cai X,Yang Y,Chen P,Ye Y,Liu X,Wu K,Yu M

Thu Sep 01 00:00:00 EDT 2016

Tetramethylpyrazine Attenuates Transdifferentiation of TGF-β2-Treated Human Tenon's Fibroblasts.

Investigative ophthalmology & visual science

Cai X,Yang Y,Chen P,Ye Y,Liu X,Wu K,Yu M

Thu Sep 01 00:00:00 EDT 2016

Exogenous H2S modulates mitochondrial fusion-fission to inhibit vascular smooth muscle cell proliferation in a hyperglycemic state.

Cell & bioscience

Sun A,Wang Y,Liu J,Yu X,Sun Y,Yang F,Dong S,Wu J,Zhao Y,Xu C,Lu F,Zhang W

Thu Jun 02 00:00:00 EDT 2016

Exogenous H2S modulates mitochondrial fusion-fission to inhibit vascular smooth muscle cell proliferation in a hyperglycemic state.

Cell & bioscience

Sun A,Wang Y,Liu J,Yu X,Sun Y,Yang F,Dong S,Wu J,Zhao Y,Xu C,Lu F,Zhang W

Thu Jun 02 00:00:00 EDT 2016

Increased expression of Talin1 in the eutopic and ectopic endometria of women with adenomyosis.

Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology

Jiang J,Sun A,Wang Y,Deng Y

Wed Jun 01 00:00:00 EDT 2016

miR-26a suppresses EMT by disrupting the Lin28B/let-7d axis: potential cross-talks among miRNAs in IPF.

Journal of molecular medicine (Berlin, Germany)

Liang H,Liu S,Chen Y,Bai X,Liu L,Dong Y,Hu M,Su X,Chen Y,Huangfu L,Li X,Gu Y,Shan H

Wed Jun 01 00:00:00 EDT 2016

Expression of Wnt/β-Catenin Signaling Pathway and Its Regulatory Role in Type I Collagen with TGF-β1 in Scleral Fibroblasts from an Experimentally Induced Myopia Guinea Pig Model.

Journal of ophthalmology

Li M,Yuan Y,Chen Q,Me R,Gu Q,Yu Y,Sheng M,Ke B

Wed Jun 01 00:00:00 EDT 2016

Expression of Wnt/β-Catenin Signaling Pathway and Its Regulatory Role in Type I Collagen with TGF-β1 in Scleral Fibroblasts from an Experimentally Induced Myopia Guinea Pig Model.

Journal of ophthalmology

Li M,Yuan Y,Chen Q,Me R,Gu Q,Yu Y,Sheng M,Ke B

Wed Jun 01 00:00:00 EDT 2016

A fundamental study on the dynamics of multiple biomarkers in mouse excisional wounds for wound age estimation.

Journal of forensic and legal medicine

Wang LL,Zhao R,Liu CS,Liu M,Li SS,Li JY,Jiang SK,Zhang M,Tian ZL,Wang M,Zhang MZ,Guan DW

Fri Apr 01 00:00:00 EDT 2016

Deletion of interleukin-6 alleviated interstitial fibrosis in streptozotocin-induced diabetic cardiomyopathy of mice through affecting TGFβ1 and miR-29 pathways.

Scientific reports

Zhang Y,Wang JH,Zhang YY,Wang YZ,Wang J,Zhao Y,Jin XX,Xue GL,Li PH,Sun YL,Huang QH,Song XT,Zhang ZR,Gao X,Yang BF,Du ZM,Pan ZW

Mon Mar 14 00:00:00 EDT 2016

An Ultra-thin Amniotic Membrane as Carrier in Corneal Epithelium Tissue-Engineering.

Scientific reports

Zhang L,Zou D,Li S,Wang J,Qu Y,Ou S,Jia C,Li J,He H,Liu T,Yang J,Chen Y,Liu Z,Li W

Mon Feb 15 00:00:00 EST 2016

IL-27 attenuates the TGF-β1-induced proliferation, differentiation and collagen synthesis in lung fibroblasts.

Life sciences

Dong Z,Zhao X,Tai W,Lei W,Wang Y,Li Z,Zhang T

Mon Feb 01 00:00:00 EST 2016

Ursolic acid attenuates diabetic mesangial cell injury through the up-regulation of autophagy via miRNA-21/PTEN/Akt/mTOR suppression.

PloS one

Lu X,Fan Q,Xu L,Li L,Yue Y,Xu Y,Su Y,Zhang D,Wang L

Fri Jan 08 00:00:00 EST 2016

High doses of (-)-epigallocatechin-3-gallate from green tea induces cardiac fibrosis in mice.

Biotechnology letters

Cai Y,He SQ,Hong HQ,Cai YP,Zhao L,Zhang M

Tue Dec 01 00:00:00 EST 2015

Ghrelin Attenuates Liver Fibrosis through Regulation of TGF-β1 Expression and Autophagy.

International journal of molecular sciences

Mao Y,Zhang S,Yu F,Li H,Guo C,Fan X

Thu Sep 10 00:00:00 EDT 2015

Establishing principles of macromolecular crowding for in vitro fibrosis research of the vocal fold lamina propria.

The Laryngoscope

Graupp M,Gruber HJ,Weiss G,Kiesler K,Bachna-Rotter S,Friedrich G,Gugatschka M

Mon Jun 01 00:00:00 EDT 2015

High Tumor Penetration of Paclitaxel Loaded pH Sensitive Cleavable Liposomes by Depletion of Tumor Collagen I in Breast Cancer.

ACS applied materials & interfaces

Zhang L,Wang Y,Yang Y,Liu Y,Ruan S,Zhang Q,Tai X,Chen J,Xia T,Qiu Y,Gao H,He Q

Wed May 13 00:00:00 EDT 2015

Surface chemistry modulates osteoblasts sensitivity to low fluid shear stress.

Journal of biomedical materials research. Part A

Xing J,Li Y,Lin M,Wang J,Wu J,Ma Y,Wang Y,Yang L,Luo Y

Sat Nov 01 00:00:00 EDT 2014

Identification of genetic loci associated with primary angle-closure glaucoma in the basset hound.

Molecular vision

Ahram DF,Cook AC,Kecova H,Grozdanic SD,Kuehn MH

Tue Sep 30 00:00:00 EDT 2014

Keratocytes create stromal spaces to promote corneal neovascularization via MMP13 expression.

Investigative ophthalmology & visual science

Ma J,Zhou D,Fan M,Wang H,Huang C,Zhang Z,Wu Y,Li W,Chen Y,Liu Z

Thu Sep 04 00:00:00 EDT 2014

Mechano growth factor E peptide regulates migration and differentiation of bone marrow mesenchymal stem cells.

Journal of molecular endocrinology

Cui H,Yi Q,Feng J,Yang L,Tang L

Tue Apr 01 00:00:00 EDT 2014

Surface functionalization of titanium substrates with cecropin B to improve their cytocompatibility and reduce inflammation responses.

Colloids and surfaces. B, Biointerfaces

Xu D,Yang W,Hu Y,Luo Z,Li J,Hou Y,Liu Y,Cai K

Tue Oct 01 00:00:00 EDT 2013

The CYP2E1 inhibitor DDC up-regulates MMP-1 expression in hepatic stellate cells via an ERK1/2- and Akt-dependent mechanism.

Bioscience reports

Liu T,Wang P,Cong M,Xu Y,Jia J,You H

Wed Jun 05 00:00:00 EDT 2013

Inhibition of farnesyl pyrophosphate synthase attenuates angiotensin II-induced cardiac hypertrophy and fibrosis in vivo.

The international journal of biochemistry & cell biology

Yang J,Zhu HH,Chen GP,Ye Y,Zhao CZ,Mou Y,Hu SJ

Fri Mar 01 00:00:00 EST 2013

Attenuating effect of Fufang Xueshuantong Capsule on kidney function in diabetic nephropathy model.

Journal of natural medicines

Zhang Q,Xiao X,Li M,Li W,Yu M,Zhang H,Sun X,Mao L,Xiang H

Tue Jan 01 00:00:00 EST 2013

Molecular events in matrix protein metabolism in the aging kidney.

Aging cell

Sataranatarajan K,Feliers D,Mariappan MM,Lee HJ,Lee MJ,Day RT,Yalamanchili HB,Choudhury GG,Barnes JL,Van Remmen H,Richardson A,Kasinath BS

Sat Dec 01 00:00:00 EST 2012

Bioinformatics

Protein Aliases: alpha 2 type I procollagen; alpha 2(I) procollagen; alpha 2(I)-collagen; alpha-1 type 1 collagen; Alpha-1 type I collagen; Alpha-2 type I collagen; alpha1 chain of type I collagen; alpha1(I) procollagen; alpha2 chain of type I collagen; COL1; COL1A1; COL1A1; matrix protein; collagen alpha 1 chain type I; Collagen alpha-1(I) chain; collagen alpha-1(I) chain preproprotein; Collagen alpha-2(I) chain; collagen COL1A2; collagen I, alpha-2 polypeptide; collagen of skin, tendon and bone, alpha-1 chain; collagen of skin, tendon and bone, alpha-2 chain; collagen type I alpha 1; collagen, type 1, alpha 1; collagen, type I, alpha 1; collagen, type I, alpha 2; osteogenesis imperfecta; pro-alpha-1 collagen type 1; procollagen type I, alpha 1; procollagen, type 1, alpha 1; procollagen, type I, alpha 1; procollagen, type I, alpha 2; Type I Collagen; type I proalpha 1; type I procollagen; type I procollagen alpha 1 chain; type I-alpha 1 collagen

Gene Aliases: AA960264; AI325291; Col1a-1; Col1a-2; COL1A1; COL1A2; Cola-1; Cola-2; Cola1; Cola2; COLIA1; EDSC; Mov-13; Mov13; OI1; OI2; OI3; OI4; oim

UniProt ID: (Human) Q15201, (Human) P08123, (Rat) P02454, (Mouse) P11087, (Mouse) Q01149, (Rat) P02466

Entrez Gene ID: (Pig) 100738123, (Human) 1277, (Human) 1278, (Pig) 100626716, (Rat) 29393, (Mouse) 12842, (Mouse) 12843, (Rat) 84352

Molecular Function: extracellular matrix structural protein