Search

  • Contáctenos
  • Orden Rápida

Nordic

Complement Polyclonal Antibody

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}

Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Additional Information:
{{banner.description}}
{{$ctrl.isSkuNotesCollapsed ? 'View more' : 'View less'}}

Product Details

RAHU-C

Applications
Tested Dilution
Publications

Immunoelectrophoresis (IE)

120 µL
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Human complement

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Storage buffer

whole serum

Contains

no preservative

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Reconstitute the lyophilized antiserum by adding 1 mL sterile distilled water.

Inter-species cross-reactivity is a normal feature of antibodies to plasma proteins, since homologous proteins of different species frequently share antigenic determinants. Crossreactivity of this antiSerum has not been tested in detail.

In immunoelectrophoresis use 2 µL human plasma or equivalent against 120 µL antiserum. In double radial immunodiffusion use a rosette arrangement with 10 µL antiserum in 3 mm diameter center well and 2 µL plasma samples (neat and serially diluted) in 2 mm diameter peripheral wells. In single radial immunodiffusion use 1 percent antiserum in the gel.

Dilutions may be prepared by adding phosphate buffered saline (PBS, pH 7.2). Repeated thawing and freezing should be avoided. If a slight precipitation occurs upon storage, this should be removed by centrifugation. It will not affect the performance of the antiserum. Diluted antiserum should be stored at 4°C, not refrozen, and preferably used the same day.

Target Information

Complement component C3 plays a central role in the activation of complement system. Its activation is required for both classical and alternative complement activation pathways. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form the mature protein, which is then further processed to generate numerous peptide products. C3 and C4, mainly produced by the liver, are the major plasma proteins of the immune system complement pathways. Measurements of serum complement components C3 and C4 are useful in the diagnosis and monitoring of immune complex disease.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

References (0)

Have you cited this product in a publication?
Let us know so we can reference it here.
Cite this product

Bioinformatics

Protein Aliases: acidic C4; Acidic complement C4; acylation-stimulating protein cleavage product; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 2; C3a anaphylatoxin; c4 propeptide; C4A anaphylatoxin; Complement C3; Complement C4-A; complement C4A (Rodgers blood group); complement component 3; complement component 4A (Rodgers blood group); complement component C3a; complement component C3b; epididymis secretory sperm binding protein Li 62p; MHC class III region complement; prepro-C3; Rodgers form of C4; unnamed protein product; ZA

View more View less

Gene Aliases: AHUS5; ARMD9; ASP; C3; C3a; C3b; C4; C4A; C4A2; C4A3; C4A4; C4A6; C4AD; C4S; CO4; CPAMD1; CPAMD2; HEL-S-62p; RG

View more View less

UniProt ID: (Human) P01024, (Human) P0C0L4

View more View less

Entrez Gene ID: (Human) 718, (Human) 720

View more View less

Function(s)
antigen binding endopeptidase inhibitor activity receptor binding protein binding chemokine activity C5L2 anaphylatoxin chemotactic receptor binding receptor agonist activity complement binding complement component C1q binding
Process(es)
positive regulation of type IIa hypersensitivity complement activation, lectin pathway activation of membrane attack complex positive regulation of protein phosphorylation positive regulation of activation of membrane attack complex immune system process complement receptor mediated signaling pathway lipid metabolic process fatty acid metabolic process inflammatory response immune response complement activation complement activation, alternative pathway complement activation, classical pathway signal transduction G-protein coupled receptor signaling pathway opsonization response to bacterium positive regulation of vascular endothelial growth factor production positive regulation of glucose transport regulation of triglyceride biosynthetic process positive regulation of lipid storage neuron remodeling leukocyte chemotaxis killing of cells of other organism oviduct epithelium development B cell activation innate immune response positive regulation of G-protein coupled receptor protein signaling pathway positive regulation of angiogenesis positive regulation of receptor-mediated endocytosis positive regulation of phagocytosis protein maturation positive regulation of phagocytosis, engulfment beta-amyloid clearance complement-dependent cytotoxicity complement-mediated synapse pruning vertebrate eye-specific patterning complement activation, GZMK pathway positive regulation of apoptotic cell clearance
guarantee_icon

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more
help_icon

We're here to help

Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

Contact tech support