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Complement C2 Polyclonal Antibody
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Product Details
BS-8613R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human Complement C2a fragment, amino acids 401-500.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Component C2 is a serum glycoprotein that functions aspart of the classical pathway of the complement system. Activated C1 cleaves C2 into C2a and C2b. The serine proteinase C2a then combines with complement factor 4b to create the C3 or C5 convertase. Deficiency of C2 has been reported to associated with certain autoimmune diseases and SNPs in this gene have been associated with altered susceptibility to age-related macular degeneration. This gene localizes within the class III region of the MHC on the short arm of chromosome 6. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described in publications but their full-length sequence has not been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: C3/C5 convertase; classical-complement pathway C3/C5 convertase; Complement C2; complement component 2; complement component C2; complement factor C2; DADB-122G4.1; MHC complement component C2; unnamed protein product
Gene Aliases: ARMD14; C2; CO2
UniProt ID: (Human) P06681, (Mouse) P21180
Entrez Gene ID: (Rat) 24231, (Human) 717, (Mouse) 12263
proteolysis
complement activation
response to nutrient
positive regulation of apoptotic cell clearance
complement activation, lectin pathway
activation of membrane attack complex
immune system process
complement activation, classical pathway
opsonization
response to bacterium
killing of cells of other organism
response to lipopolysaccharide
innate immune response
protein maturation
response to thyroid hormone
complement activation, GZMK pathway
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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