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Invitrogen
Complement C3 Polyclonal Antibody
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FIGURE: 1 / 6
Complement C3 Antibody (PA1-29715) in ICC/IF
ASN neuro 2022 -
Figure 7. Assessment of the functional state of reactive astrocytes after TMT exposure. Double immunofluorescent staining of GFAP and IL-1beta, TNF-alpha, IL-10, C3, iNOS and NF-kB and corresponding integrated fluorescence density expressed as AUs +- SEM in the injured CA area at 7 and 21 dpi. Significance shown inside the graphs: * p < .05 or less compared to age-match Ctrl. Note . AU = arbitrary unit; Ctr... View More
Product Details
PA1-29715
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Baboon,
Horse,
Guinea pig,
Hamster,
Human,
Mouse,
Pig,
Rabbit,
Rat
Published species
C. elegans,
Cynomolgus monkey,
Guinea pig,
Human,
Mouse,
Rat
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Human complement C3.
Conjugate
Form
Liquid
Concentration
94 mg/mL
Storage buffer
50mM tris HCl, pH 7.5, with 500mM NaCl
Contains
0.1% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Specificity: Monospecific to human C3 complement component. This antibody has also been reported to recognize the C3 fragments, C3a, C3b and C3c.
Product is supplied as diluted unpurified antiserum. Store as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
C3 is a key component of the complement system since classical and alternative activation pathways merge at the C3 activation step when C3 is split into C3a and C3b. The molecular mass of C3 is 185 kDa and it consists of two chains (110 kDa and 75 kDa) held together by disulfide bonds.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: acylation-stimulating protein cleavage product; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1; C3a anaphylatoxin; Complement C3; complement C3 protein (GPC3) precursor; complement component 3; complement component C3; complement component C3 alpha-chain; complement component C3a; complement component C3b; epididymis secretory sperm binding protein Li 62p; HSE-MSF; prepro-C3
Gene Aliases: AHUS5; AI255234; ARMD9; ASP; C3; C3a; C3b; C3d; CPAMD1; HEL-S-62p; HSE-MSF; I79_008227; Plp
UniProt ID: (Guinea pig) P12387, (Rat) P01026, (Human) P01024, (Mouse) P01027, (Pig) P01025
positive regulation of type IIa hypersensitivity
positive regulation of protein phosphorylation
positive regulation of activation of membrane attack complex
tolerance induction
fatty acid metabolic process
chemotaxis
inflammatory response
complement activation
complement activation, alternative pathway
complement activation, classical pathway
blood coagulation
positive regulation of vascular endothelial growth factor production
positive regulation of glucose transport
regulation of triglyceride biosynthetic process
positive regulation of lipid storage
negative regulation of endopeptidase activity
response to magnesium ion
response to estradiol
response to progesterone
response to estrogen
positive regulation of G-protein coupled receptor protein signaling pathway
positive regulation of angiogenesis
positive regulation of developmental growth
positive regulation of phagocytosis
response to glucocorticoid
positive regulation of ERK1 and ERK2 cascade
positive regulation of apoptotic cell clearance
proteolysis
immune response
signal transduction
G-protein coupled receptor signaling pathway
regulation of complement activation
regulation of immune response
innate immune response
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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