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Invitrogen
Complement C3 Polyclonal Antibody
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FIGURE: 1 / 6
Complement C3 Antibody (PA1-29715) in ICC/IF
ASN neuro 2022 -
Figure 7. Assessment of the functional state of reactive astrocytes after TMT exposure. Double immunofluorescent staining of GFAP and IL-1beta, TNF-alpha, IL-10, C3, iNOS and NF-kB and corresponding integrated fluorescence density expressed as AUs +- SEM in the injured CA area at 7 and 21 dpi. Significance shown inside the graphs: * p < .05 or less compared to age-match Ctrl. Note . AU = arbitrary unit; Ctr... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA1-29715
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Baboon,
Horse,
Guinea pig,
Hamster,
Human,
Mouse,
Pig,
Rabbit,
Rat
Published species
Cynomolgus monkey,
Guinea pig,
Human,
Mouse,
Rat
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Human complement C3.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
89 mg/mL
Amount
89 mg
Storage buffer
50mM tris HCl, pH 7.5, with 500mM NaCl
Contains
0.1% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Specificity: Monospecific to human C3 complement component. This antibody has also been reported to recognize the C3 fragments, C3a, C3b and C3c.
Product is supplied as diluted unpurified antiserum. Store as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
C3 is a key component of the complement system since classical and alternative activation pathways merge at the C3 activation step when C3 is split into C3a and C3b. The molecular mass of C3 is 185 kDa and it consists of two chains (110 kDa and 75 kDa) held together by disulfide bonds.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: acylation stimulating protein; acylation-stimulating protein cleavage product; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1; C3 convertase cleavage product; C3a anaphylatoxin; complement 3; Complement C3; complement C3 protein (GPC3) precursor; complement component 3; complement component 3d; complement component C3; complement component C3 alpha-chain; complement component C3 precursor; complement component C3a; complement component C3b; complement factor 3; epididymis secretory sperm binding protein Li 62p; prepro-C3; preprocomplement component C3; unnamed protein product
Gene Aliases: AHUS5; ARMD9; ASP; C3a; C3b; C3d; CPAMD1; HEL-S-62p; HSE-MSF; I79_008227; Plp
UniProt ID: (Mouse) P01027, (Rat) P01026, (Guinea pig) P12387, (Human) P01024, (Pig) P01025
positive regulation of type IIa hypersensitivity
complement activation, lectin pathway
activation of membrane attack complex
positive regulation of protein phosphorylation
positive regulation of activation of membrane attack complex
complement receptor mediated signaling pathway
proteolysis
inflammatory response
complement activation
complement activation, alternative pathway
complement activation, classical pathway
opsonization
response to bacterium
positive regulation of vascular endothelial growth factor production
positive regulation of glucose transport
regulation of triglyceride biosynthetic process
positive regulation of lipid storage
neuron remodeling
regulation of complement activation
regulation of complement activation, alternative pathway
leukocyte chemotaxis
killing of cells of other organism
oviduct epithelium development
vascular smooth muscle cell differentiation
B cell activation
positive regulation of G-protein coupled receptor protein signaling pathway
positive regulation of angiogenesis
positive regulation of receptor-mediated endocytosis
positive regulation of developmental growth
positive regulation of phagocytosis
protein maturation
retina development in camera-type eye
positive regulation of phagocytosis, engulfment
positive regulation of ERK1 and ERK2 cascade
positive regulation of glomerular mesangial cell proliferation
beta-amyloid clearance
complement-dependent cytotoxicity
complement-mediated synapse pruning
vertebrate eye-specific patterning
complement activation, GZMK pathway
positive regulation of opsonization
positive regulation of sensory perception of pain
negative regulation of vascular smooth muscle contraction
positive regulation of apoptotic cell clearance
tolerance induction
response to xenobiotic stimulus
response to magnesium ion
response to estradiol
response to progesterone
response to estrogen
innate immune response
response to glucocorticoid
innervation
immune response
signal transduction
G-protein coupled receptor signaling pathway
positive regulation of immune response
response to other organism
fatty acid metabolic process
negative regulation of endopeptidase activity
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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