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Invitrogen
Complement C4 Monoclonal Antibody (16D2)
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Product Details
MA1-40047
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse
Published species
Mouse
Host/Isotype
Rat
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
16D2
Immunogen
Thymocytes decorated with Thy-1 antibody and complement components
Conjugate
Form
Liquid
Concentration
100 µg/mL
Amount
100 µg
Purification
Protein G
Storage buffer
PBS with 0.1% BSA
Contains
0.02% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
MA1-40047 detects C4 from mouse samples.
MA1-40047 has been successfully used in immunohistochemistry (frozen), immunoprecipitation, ELISA, immunofluorescence and Western blot applications.
The MA1-40047 immunogen is mouse complement factor C4.
Suggested positive Control: T-cell regions of Mouse spleen.
Target Information
This gene encodes the acidic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain may be cleaved to release C4 anaphylatoxin, a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus and type I diabetes mellitus. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist, such that individuals may have 1, 2, or 3 copies of this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: c4 complement; Complement C4-A; Complement C4-B; complement component 4 (within H-2S); complement component 4B (Childo blood group); DADB-112B14.11; DAMC-258G8.6; FLJ60561; MGC164979; Sex-limited protein
Gene Aliases: C4; C4a; C4b; Slp; Ss
UniProt ID: (Mouse) A0AAQ4VMX2, (Mouse) P01029
Entrez Gene ID: (Mouse) 625018, (Mouse) 12268
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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