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Complement C4b Antibody (PA5-119043) in IHC (P)
Immunohistochemistry analysis of Complement C4b in paraffin-embedded Human Small Intestine tissue. Samples were incubated with polyclonal antibody (Product # PA5-119043) at a dilution of 20 µg/mL, followed by HRP-Linked Caprine Anti-Rabbit IgG using a dilution of 2 µg/mL.
Product Details
PA5-119043
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein Complement C4-B. The antigen corresponds to amino acid range 680-756 of the target protein.
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS with 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2903543
Target Information
This gene encodes the basic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain may be cleaved to release C4 anaphylatoxin, a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist, such that individuals may have 1, 2, or 3 copies of this gene. In addition, this gene exists as a long form and a short form due to the presence or absence of a 6.4 kb endogenous HERV-K retrovirus in intron 9.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Acidic complement C4; Basic complement C4; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 2; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 3; c4 complement; C4A13; C4A91; Chido form of C4; Complement C4-A; Complement C4-B; complement C4B1a; DADB-112B14.11; FLJ60561; MGC164979
Gene Aliases: C4A; C4B; C4B1; C4B12; C4B2; C4B3; C4B5; C4B_2; C4BD; C4F; CH; CO4; CPAMD2; CPAMD3
UniProt ID: (Human) P01028, (Human) P0C0L5
Entrez Gene ID: (Human) 721, (Human) 100293534
proteolysis
inflammatory response
complement activation
complement activation, classical pathway
opsonization
negative regulation of endopeptidase activity
regulation of complement activation
detection of molecule of bacterial origin
innate immune response
positive regulation of apoptotic cell clearance
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