Search
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Invitrogen
Complement C4b/C4c Polyclonal Antibody, FITC
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
FIGURE: 1 / 1
Complement C4b/C4c Antibody (PA1-28407)
Fig 3 Studies of ficolin-2 binding and ficolin-2-mediated complement deposition. A, ficolin-2 (FCN2) binds to representative serotype 11A, 35B, and 31 strains but not their isogenic O-acetyl transferase-deficient derivatives (11E, 35D, and 31X1). Bacteria were incubated with buffer (light gray fill), 10% heat-inactivated normal human serum (dark gray line), or 10% normal human serum (black line) for 1 hour ... View More
Product Details
PA1-28407
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
C. elegans,
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
C4c complement isolated from complement activated human serum.
Conjugate
Excitation/Emission Max
498/517 nm
View spectra
Form
Liquid
Concentration
Conc. Not Determined
Purification
IgG fraction
Storage buffer
PBS
Contains
0.09% sodium azide
Storage conditions
4°C, store in dark
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
PA1-28407 detects C4c / C4b from human samples.
Antigen retrieval for IHC (P): Proteinase K 30 min at 37°C
Target Information
This gene encodes the acidic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain may be cleaved to release C4 anaphylatoxin, a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus and type I diabetes mellitus. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist, such that individuals may have 1, 2, or 3 copies of this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Acidic complement C4; Basic complement C4; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 2; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 3; c4 complement; C4A2; C4A3; C4A4; C4A6; C4S; Chido form of C4; Complement C4-A; Complement C4-B; complement C4B1a; DAMC-258G8.6; MGC164979; RG
Gene Aliases: C4A; C4B; C4B1; C4B12; C4B2; C4B3; C4B5; C4B_2; C4BD; C4F; CH; CO4; CPAMD2; CPAMD3
UniProt ID: (Human) P01028, (Human) P0C0L5
Entrez Gene ID: (Human) 721, (Human) 100293534
proteolysis
inflammatory response
complement activation
complement activation, classical pathway
opsonization
negative regulation of endopeptidase activity
regulation of complement activation
detection of molecule of bacterial origin
innate immune response
positive regulation of apoptotic cell clearance
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support