PA1-28407 detects C4c / C4b from human samples.
This gene encodes the acidic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain may be cleaved to release C4 anaphylatoxin, a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus and type I diabetes mellitus. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist, such that individuals may have 1, 2, or 3 copies of this gene.
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Protein Aliases: Acidic complement C4; Basic complement C4; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 2; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 3; c4 complement; C4a anaphylatoxin; C4A2; C4A3; C4A4; C4A6; C4b-A; C4b-B; C4d-A; C4d-B; Chido form of C4; Complement C4 beta chain; Complement C4 gamma chain; Complement C4-A; Complement C4-A alpha chain; Complement C4-B; Complement C4-B alpha chain; complement C4B1a; DAMC-258G8.6; MGC164979; RG
Gene Aliases: C4A; C4B; C4B1; C4B12; C4B2; C4B3; C4B5; C4B_2; C4BD; C4F; CH; CO4; CPAMD2; CPAMD3
UniProt ID: (Human) P0C0L4
Entrez Gene ID: (Human) 721