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Invitrogen
Complement C5 Polyclonal Antibody
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Product Details
PA1-40289
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Murine C5.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS with 0.1% BSA
Contains
0.02% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
PA1-40289 detects C5 from mouse samples.
PA1-40289 has been successfully used in Western blot applications.
The PA1-40289 imunogen is mouse C5.
Target Information
The protein encoded by this gene is the fifth component of complement, which plays an important role in inflammatory and cell killing processes. This protein is comprised of alpha and beta polypeptide chains that are linked by a disulfide bridge. An activation peptide, C5a, which is an anaphylatoxin that possesses potent spasmogenic and chemotactic activity, is derived from the alpha polypeptide via cleavage with a convertase. The C5b macromolecular cleavage product can form a complex with the C6 complement component, and this complex is the basis for formation of the membrane attack complex, which includes additional complement components. Mutations in this gene cause complement component 5 deficiency, a disease where patients show a propensity for severe recurrent infections. Defects in this gene have also been linked to a susceptibility to liver fibrosis and to rheumatoid arthritis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: C4B1; C4B12; C4B2; C4B3; C4B5; C4F; CH; CO4; complement component C5D; complement component C5S precursor; CPAMD3; DADB-112B14.11; FLJ17816; FLJ17822; FLJ60561; hepatic fibrogenesis 2; MGC142298; MGC164979; unnamed protein product
Gene Aliases: C5; C5a; He; Hfib2
UniProt ID: (Mouse) P06684
Entrez Gene ID: (Mouse) 15139
in utero embryonic development
neutrophil homeostasis
kidney development
complement activation, lectin pathway
immune system process
leukocyte migration involved in inflammatory response
cellular calcium ion homeostasis
chemotaxis
inflammatory response
complement activation
complement activation, alternative pathway
complement activation, classical pathway
positive regulation of cytosolic calcium ion concentration
positive regulation of vascular endothelial growth factor production
negative regulation of norepinephrine secretion
negative regulation of macrophage chemotaxis
leukocyte chemotaxis
killing of cells of other organism
positive regulation of chemokine production
glomerulus development
negative regulation of dopamine secretion
positive regulation of angiogenesis
positive regulation of chemotaxis
transmembrane transport
inflammatory response to wounding
complement activation, GZMK pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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