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Invitrogen
Complement C5b-9 Monoclonal Antibody (3R2/0)
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Product Details
MA5-28502
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Rat
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
3R2/0
Conjugate
Form
Liquid
Concentration
1.093 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
BBS
Contains
<0.1% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody recognizes the SC5b-9 complex of around 330 kDa. Both the classical and alternative complement pathways result in the formation of the cytolysis inducing C5b-9 complex.
Target Information
The complement system is a fundamental part of innate immunity, consisting of over 45 genes that encode various complement components, regulators, and receptors. The complement C5b-9 complex, also known as the Membrane Attack Complex (MAC), plays a crucial role in the immune defense mechanism. It includes the sequential assembly of proteins C5b, C6, C7, C8, and multiple copies of C9. This complex forms transmembrane channels that puncture the cell membrane of target cells, leading to cell lysis. Specifically, MAC has significant implications in mediating cell death in both pathogenic organisms and cancer cells. The genes involved are clustered across the human genome, mainly organized in three significant loci. The understanding of the C5b-9 complex's function extends beyond its antimicrobial roles to include its interactions with tumor cells, where it can induce cell death and influence cancer progression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: anaphylatoxin C5a analog; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4; C5a anaphylatoxin; C5b-9; C9 complement protein; Complement C5; complement component 5; complement component 6; complement component 7; complement component 9; Complement component C6; complement component C6 precursor peptide; Complement component C7; Complement component C9; complement protein C7 precursor; MAC Complex; Membrane Attack Complex; prepro-C5; unnamed protein product
Gene Aliases: ARMD15; C5; C5a; C5b; C5D; C6; C7; C9; C9D; CPAMD4; ECLZB
UniProt ID: (Human) P01031, (Human) P13671, (Human) P10643, (Human) P02748
Entrez Gene ID: (Human) 727, (Human) 729, (Human) 730, (Human) 735
cell killing
immune system process
immune response
complement activation
complement activation, alternative pathway
complement activation, classical pathway
killing of cells of other organism
innate immune response
positive regulation of immune response
protein homooligomerization
complement activation, GZMK pathway
complement activation, lectin pathway
regulation of immune system process
chemotaxis
inflammatory response
signal transduction
cell surface receptor signaling pathway
G-protein coupled receptor signaling pathway
positive regulation of vascular endothelial growth factor production
negative regulation of macrophage chemotaxis
cell migration
leukocyte chemotaxis
positive regulation of chemokine production
regulation of chemotaxis
cell chemotaxis
in utero embryonic development
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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