This antibody recognizes the SC5b-9 complex of around 330 kDa. Both the classical and alternative complement pathways result in the formation of the cytolysis inducing C5b-9 complex.
An association study of C5 haplotypes and genotypes in individuals with chronic hepatitis C virus infection shows that individuals homozygous for the C5_1 haplotype have a significantly higher stage of liver fibrosis than individuals carrying at least 1 other allele.
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Protein Aliases: anaphylatoxin C5a analog; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4; C5a anaphylatoxin; c5b-9; C5b9; Complement C5; Complement C5 alpha chain; Complement C5 alpha' chain; Complement C5 beta chain; Complement component C9; Complement component C9a; Complement component C9b; prepro-C5
Gene Aliases: ARMD15; C5; C5a; C5b; C5D; C9; C9D; CPAMD4; ECLZB
Molecular Function: protease inhibitor