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Invitrogen
Complement C9 Monoclonal Antibody (aE11)
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Product Details
MA5-33373
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Horse,
Human,
Pig
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
aE11
Conjugate
Form
Liquid
Concentration
100 µg/mL
Purification
Protein G
Storage buffer
PBS with 0.1% BSA
Contains
no preservative
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Product is supplied at 1 mL (100 µL/mL). This antibody reacts with a C9 neoantigen of the terminal complement complex (TCC).
Application Notes: Functional Assay - This antibody inhibits platelet activation by antiphospholipid antibody serum. IF - Cryosections of 10 µm were dried, fixed in acetone at 4°C for 10 min, dried and blocked for 20 min with PBSA. Positive control: Mucosa from patients with H. Pylori.
Target Information
C5b-9 membrane attack complexes are assembled from five precursor molecules in the serum. Proteolytic cleavage of C5 by C5 convertase generates C5b which initiates assembly of the C5b-9 complex. The last step of C5b-9 complex formation involves polymerization of C9 which accompanies insertion of the complex into the cell membrane. During formation of C5b-8 and C9 polymerization, neoantigens are generated which are unique to the C5b-9 complex and are not present on any of the individual native complex components. The complement regulatory proteins CD59 and complement S-protein can both prevent C5b-9 insertion into the cell membrane. The formed SC5b-9 complex is unable to attach to cells and is cytolytically inactive. C5b-9 is involved in the progression of chronic proteinuric renal disease by mediating continuous tubulointerstitial damage. Early tubulointerstitial injury in the remnant kidney can be improved when C5b-9 complex forming is abrogated.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Complement component C9; complement protein C9
Gene Aliases: ARMD15; C9; C9D
UniProt ID: (Human) P02748, (Horse) P48770
Entrez Gene ID: (Pig) 100037951, (Human) 735, (Horse) 100034183
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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