In direct ELISAs, approximately 10% cross-reactivity with recombinant mouse Complement Factor D is observed, and less than 1% cross-reactivity with recombinant human (rh) Complement Factor B and rhComplement Factor I is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
Complement factor D is a serine protease of the alternative pathway of complement activation. The protein is a single chain polypeptide with a molecular mass of 25 kDa. Factor D cleaves factor B bound to C3b, generating the alternative pathway C3 convertase C3bBb and releasing the Ba fragment.
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Protein Aliases: Adipsin; C3 convertase activator; Complement factor D; complement factor D (adipsin); complement factor D preproprotein; D component of complement (adipsin); EC 188.8.131.52; Properdin factor D
Gene Aliases: ADIPSIN; ADN; CFD; DF; PFD
UniProt ID: (Human) P00746
Entrez Gene ID: (Human) 1675