|Tested species reactivity||Human, Mouse|
|Published species reactivity||Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide derived from the C-terminal region of the mouse, rat, golden and Chinese hamster, and predicted dog connexin 37 proteins, which differ from human and chimpanzee by two conservative amino acid changes|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7.4|
|Contains||0.1% sodium azide|
|Tested Applications||Dilution *|
|Immunohistochemistry (Frozen) (IHC (F))||1:10-1:50|
|Immunohistochemistry (Paraffin) (IHC (P))||1:10-1:50|
|Western Blot (WB)||2 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
42-4400 was used in the western blot analysis to successfully detect Connexin 37 in mouse lung homogenate.
This gene encodes a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. Mutations in this gene have been associated with atherosclerosis and a higher risk of myocardial infarction.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
NO, via its target Cx37, modulates calcium signal propagation selectively at myoendothelial gap junctions.
42-4400 was used in immunocytochemistry to study the effect of NO on the gap junctional calcium signal propagation in endothelial cells and determine the distribution of the vascular connexins in small resistance arteries.
|Pogoda K,Füller M,Pohl U,Kameritsch P||Cell communication and signaling : CCS (12:null)||2014|
|Mouse||Not Cited||TIMP-2 mutant decreases MMP-2 activity and augments pressure overload induced LV dysfunction and heart failure.||Givvimani S,Kundu S,Narayanan N,Armaghan F,Qipshidze N,Pushpakumar S,Vacek TP,Tyagi SC||Archives of physiology and biochemistry (119:65)||2013|
|Mouse||Not Cited||Cx37 and Cx43 localize to zona pellucida in mouse ovarian follicles.||Simon AM,Chen H,Jackson CL||Cell communication and adhesion (13:61)||2006|