Invitrogen

Connexin 40 Polyclonal Antibody

View all (8) Connexin 40 antibodies

Questions & Answers

Questions & Answers

Product Details

PA1-18406

Applications	Tested Dilution	Publications
Western Blot (WB)	1:10,000-1:50,000	-

Product Specifications
Species Reactivity	Rat
Host/Isotype	Sheep / IgG
Class	Polyclonal
Type	Antibody
Immunogen	Synthetic peptide corresponding to residues S(253) L V Q G L T P P P D F N Q C L K(269) of rat Connexin-40.
Conjugate	Unconjugated
Form	Lyophilized
Concentration	Conc. Not Determined
Storage buffer	whole serum
Contains	no preservative
Storage conditions	-20° C, Avoid Freeze/Thaw Cycles
RRID	AB_2110472

Product Specific Information

PA1-18406 detects Connexin-40 from rat samples.

PA1-18406 has been successfully used in Western blot procedures.

The PA1-18406 immunogen is a synthetic peptide corresponding to residues S(253) L V Q G L T P P P D F N Q C L K(269) of rat Connexin-40, conjugated to diphtheria toxoid.

After reconstitution keep aliquots at -20°C for a higher stability or at 4°C with an appropriate antibacterial agent. Glycerol (1:1) may be added for an additional stability. Avoid repeated freeze/thaw cycles.

Reconstitute with 100 µL of distilled water.

Target Information

Connexin 40 (Cx40), belongs to the connexin family of gap junction proteins, which are expressed in pancreas, kidney, skeletal muscle, liver, placenta and heart. Connexin 40 is highly expressed in vascular endothelial cells, and the mammalian heart (specifically in the atrial myocardium, and the His-Purkinje conduction system). At least three other connexins are expressed in the heart, including Cx37 (endocardium), Cx43 (atrial and ventricular myocardium, and distal parts of the conduction system) and Cx45 (throughout the heart). Cx40 and Cx43 frequently co-localize in cells of the cardiovascular system and participate in the formation of heterotypic gap junction channels.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: connexin 40; Connexin-40; Cx40; Gap junction alpha-5 protein; gap junction membrane channel protein alpha 5

Gene Aliases: Cx40; Cxn-40; Gja5

UniProt ID: (Rat) P28234

Entrez Gene ID: (Rat) 50563

Molecular Function: gap junction

skeletal system development angiogenesis blood vessel development renal system process involved in regulation of systemic arterial blood pressure regulation of systemic arterial blood pressure negative regulation of glomerular filtration outflow tract morphogenesis endothelium development cardiac conduction system development mitral valve development pulmonary valve formation ventricular septum development atrial septum development septum primum development atrial ventricular junction remodeling potassium ion transport heart development cell communication by chemical coupling cell communication by electrical coupling positive regulation of cell communication by chemical coupling gap junction assembly embryonic limb morphogenesis embryonic heart tube development foramen ovale closure regulation of vasodilation negative regulation of blood pressure positive regulation of vasoconstriction positive regulation of vasodilation artery morphogenesis protein oligomerization transmembrane transport regulation of cardiac muscle contraction regulation of ventricular cardiac muscle cell membrane repolarization regulation of atrial cardiac muscle cell membrane depolarization regulation of ventricular cardiac muscle cell membrane depolarization ventricular septum morphogenesis atrial septum morphogenesis cardiac conduction ventricular cardiac muscle cell action potential atrial cardiac muscle cell action potential SA node cell action potential AV node cell to bundle of His cell communication by electrical coupling cell communication by electrical coupling involved in cardiac conduction cell communication involved in cardiac conduction AV node cell to bundle of His cell communication bundle of His cell to Purkinje myocyte communication regulation of heart rate by cardiac conduction regulation of renin secretion into blood stream regulation of membrane depolarization during cardiac muscle cell action potential vasomotion

Process(es)

gap junction channel activity gap junction hemi-channel activity connexin binding gap junction channel activity involved in cardiac conduction electrical coupling gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling