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Product Details
OSC00012W-100UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse,
Rat
Published species
Not Applicable
Host/Isotype
Rabbit
/ Ig
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide from aa region 550-600 of rat Contactin 2 conjugated to blue carrier protein was used as the antigen
Conjugate
Form
Lyophilized
Concentration
Conc. Not Determined
Storage buffer
whole serum
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
The peptide is homologous in mouse.
Specificity of this antibody: contactin-2.
Target Information
Contactin 2 (CNTN2, transiently-expressed axonal glycoprotein, AXT, TAX, TAX1, TAG-1, axonin 1) is a neuronal cell adhesion molecule (CAM) that influences the formation of axon connections in the developing nervous system. Contactin 2 is a member of the immunoglobulin superfamily (IgSF) and contains a glycosylphosphatidylinositol-anchor, six immunoglobulin (Ig)-like and four Fibronectin type III (FNIII)-like domains. Contactin 2 is expressed predominantly during neural development on the cell membrane of axons in nerve fiber tracts in order to guide commissural axons without promoting their growth. Contactin 2 binds with NgCAM in the plane of the same membrane (cis-binding). The Contactin 2 heterophilic (Contactin 2/NgCAM and Contactin 2/NrCAM) binding sites are localized to the first four Ig domains. The Contactin 2 homophilic (Contactin 2/Contactin 2) binding site is localized to the FNIII domain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Axonal glycoprotein TAG-1; axonin; Axonin 1; Axonin-1; Axonin1; Contactin-2; Contactin2; DKFZp781D102; MGC157722; TAX-1; Transient axonal glycoprotein 1; transiently-expressed axonal glycoprotein
Gene Aliases: Cntn2; D130012K04Rik; TAG-1; TAG-564; TAG1; Tax; Tax1
UniProt ID: (Mouse) Q61330, (Rat) P22063
Entrez Gene ID: (Mouse) 21367, (Rat) 25356
microtubule cytoskeleton organization
neuron migration
cell adhesion
cell-matrix adhesion
axonogenesis
axon guidance
axonal fasciculation
learning
adult walking behavior
regulation of cell morphogenesis involved in differentiation
positive regulation of protein processing
cerebral cortex GABAergic interneuron migration
central nervous system myelination
regulation of axon diameter
neuron projection development
receptor internalization
clustering of voltage-gated potassium channels
negative regulation of neuron differentiation
regulation of neuronal synaptic plasticity
regulation of astrocyte differentiation
positive regulation of adenosine receptor signaling pathway
protein localization to juxtaparanode region of axon
establishment of protein localization to juxtaparanode region of axon
presynaptic membrane organization
cellular protein localization
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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