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Invitrogen
Cripto Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-17191
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to amino acids near the amino terminus of mouse Cripto
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
151 µg/mL
Amount
15.1 µg
Purification
Antigen affinity chromatography
Storage buffer
0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol
Contains
no preservative
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
Cripto (TDGF1) is a GPI-anchored cell membrane proetin involved in Nodal signaling. Cell associated TDGF1 acts as a a Nodeal coreceptor in cis. Shedding of TDGF1 by TMEM8A modulated Nodal signaling by allowing soluble TDGF1 to act as a Nodal coreceptor on other cells. TDGF1 is expressed both in ES cells and during the early phases of embryo development, while in adults it is reactivated in a wide range of epithelial cancers.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: cripto; cripto growth factor; Cripto-1; Cripto-3; epidermal growth factor-like Cripto protein; TDGF2; teratocarcinoma-derived growth factor 1; TERATOCARCINOMA-DERIVED GROWTH FACTOR PRECURSOR (EPIDERMAL GROWTH FACTOR-LIKE CRIPTO PROTEIN) (CRIPTO GROWTH FACTOR); unnamed protein product
Gene Aliases: CR1; Tdgf1
UniProt ID: (Mouse) P51865
Entrez Gene ID: (Mouse) 21667
blood vessel development
vasculogenesis
in utero embryonic development
morphogenesis of a branching structure
positive regulation of cell-matrix adhesion
determination of left/right symmetry
gastrulation
heart development
positive regulation of cell proliferation
anterior/posterior axis specification, embryo
anterior/posterior axis specification
anterior/posterior pattern specification
regulation of signal transduction
cell differentiation
regulation of cell migration
positive regulation of cell migration
negative regulation of transforming growth factor beta receptor signaling pathway
nodal signaling pathway
positive regulation of MAP kinase activity
positive regulation of transcription from RNA polymerase II promoter
positive regulation of fibroblast proliferation
cardiac muscle cell differentiation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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