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Invitrogen
Cripto Monoclonal Antibody (05)
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Product Details
MA5-43010
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
05
Immunogen
Recombinant Human Cripto/TDGF1/ CRGF protein (1-172).
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Specificity: Human Cripto/TDGF1/ CRGF
Target Information
Cripto (TDGF1) is a GPI-anchored cell membrane proetin involved in Nodal signaling. Cell associated TDGF1 acts as a a Nodeal coreceptor in cis. Shedding of TDGF1 by TMEM8A modulated Nodal signaling by allowing soluble TDGF1 to act as a Nodal coreceptor on other cells. TDGF1 is expressed both in ES cells and during the early phases of embryo development, while in adults it is reactivated in a wide range of epithelial cancers.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CRGF; Cripto, EGF-CFC family member; Cripto-1; Cripto-1 growth factor; Cripto-3; Epidermal growth factor-like cripto protein CR1; Protein Cripto; TDGF2; Teratocarcinoma-derived growth factor 1; unnamed protein product
Gene Aliases: CR; CR-1; CRGF; CRIPTO; CRIPTO-1; TDGF1
UniProt ID: (Human) P13385
Entrez Gene ID: (Human) 6997
blood vessel development
morphogenesis of a branching structure
cell migration involved in sprouting angiogenesis
signal transduction
epidermal growth factor receptor signaling pathway
determination of left/right symmetry
heart development
positive regulation of cell proliferation
anterior/posterior axis specification, embryo
embryo development ending in birth or egg hatching
anterior/posterior pattern specification
regulation of signal transduction
positive regulation of endothelial cell migration
cell differentiation
positive regulation of cell migration
mammary gland development
cellular response to hepatocyte growth factor stimulus
nodal signaling pathway
negative regulation of apoptotic process
positive regulation of MAP kinase activity
positive regulation of MAPK cascade
cellular response to fibroblast growth factor stimulus
cellular response to interferon-gamma
cellular response to interleukin-6
cellular response to tumor necrosis factor
cellular response to epidermal growth factor stimulus
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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