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This gene encodes a membrane-bound inhibitor of complement activation, which contains several tandemly arranged short consensus repeats (SCRs) of approximately 60 amino acids. The encoded protein may play a role in tumor immune surveillance, which is unrelated to complement inhibition. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
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Protein Aliases: 5I2 antigen; Antigen 5I2; Complement C4b-binding protein CR-1-like protein; complement component (3b/4b) receptor 1-like; Complement component receptor 1-like protein; Complement receptor related protein; complement receptor type 1; Complement regulatory protein Crry; MGC129536; Protein p65
Gene Aliases: Cr1; CR1L; Crry; Cry; Mcp; mCRY
UniProt ID: (Human) Q2VPA4, (Mouse) Q64735, (Rat) Q63135
Entrez Gene ID: (Human) 1379, (Mouse) 12946, (Rat) 54243
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