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Proteintech
Cryptochrome 1 Polyclonal Antibody
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Product Details
13474-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Cryptochrome 1 Fusion Protein Ag4270 (236-586 aa encoded by BC030519)
Conjugate
Form
Liquid
Concentration
0.19 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: RPRMNANSL LASPTGLSPY LRFGCLSCRL FYFKLTDLYK KVKKNSSPPL SLYGQLLWRE FFYTAATNNP RFDKMEGNPI CVQIPWDKNP EALAKWAEGR TGFPWIDAIM TQLRQEGWIH HLARHAVACF LTRGDLWISW EEGMKVFEEL LLDADWSINA GSWMWLSCSS FFQQFFHCYC PVGFGRRTDP NGDYIRRYLP VLRGFPAKYI YDPWNAPEGI QKVAKCLIGV NYPKPMVNHA EASRLNIERM KQIYQQLSRY RGLGLLASVP SNPNGNGGFM GYSAENIPGC SSSGSCSQGS GILHYAHGDS QQTHLLKQGR SSMGTGLSGG KRPSQEEDTQ SIGPKVQRQS TN (236-586 aa encoded by BC030519)
Target Information
Various biochemical, physiological and behavioral processes display circadian rhythms controlled by an internal biological clock. The central "gears" driving this clock appear to be composed of an autoregulatory transcription/post translation-based feedback loop. Cryptochrome 1 (CRY1) and 2 (CRY2) are DNA-binding flavoproteins that bear some homology to blue-light receptors and photolyases. In Drosophila, CRY is a photoreceptor for the circadian clock where it binds to the clock component TIM in a light-dependent fashion and blocks its function. Mammalian CRY1 and CRY2 function via light-independent interactions with circadian genes CLOCK and BMAL1, as well as with PER1, PER2, and TIM. They seem to act as light-independent components of the circadian clock and likely regulate Per1 transcriptional cycling via interactions with both the activator and its feedback inhibitors. Mutant mice not expressing the Cry1 or Cry2 protein display accelerated and delayed periodicity of locomotor activity, respectively. It appears that the combination of both proteins working together is essential to synchronize the organism to circadian phases. A critical balance between Cry1 and Cry2 is required for proper clock function; in complete darkness, double-mutant mice present with instantaneous arrhythmicity, indicating the absence of an internal circadian clock.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: cryptochrome 1 (photolyase-like); Cryptochrome-1
Gene Aliases: AU020726; AU021000; CRY1; PHLL1
UniProt ID: (Human) Q16526, (Rat) Q32Q86, (Mouse) P97784
Entrez Gene ID: (Human) 1407, (Rat) 299691, (Mouse) 12952
nucleotide binding
transcription factor activity, transcription factor binding
core promoter sequence-specific DNA binding
core promoter binding
DNA binding
double-stranded DNA binding
deoxyribodipyrimidine photo-lyase activity
DNA (6-4) photolyase activity
protein binding
transcription factor binding
blue light photoreceptor activity
protein kinase binding
phosphatase binding
nuclear hormone receptor binding
histone deacetylase binding
ubiquitin binding
DNA photolyase activity
photoreceptor activity
kinase binding
DNA photolyase
negative regulation of transcription from RNA polymerase II promoter
gluconeogenesis
transcription, DNA-templated
DNA damage induced protein phosphorylation
blue light signaling pathway
protein-chromophore linkage
lipid storage
negative regulation of protein ubiquitination
response to insulin
circadian regulation of gene expression
response to glucagon
glucose homeostasis
regulation of circadian rhythm
negative regulation of circadian rhythm
entrainment of circadian clock by photoperiod
negative regulation of G-protein coupled receptor protein signaling pathway
negative regulation of transcription, DNA-templated
regulation of DNA damage checkpoint
negative regulation of glucocorticoid receptor signaling pathway
negative regulation of glucocorticoid secretion
DNA repair
signal transduction
circadian rhythm
regulation of transcription, DNA-templated
rhythmic process
response to stimulus
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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