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Immunogen sequence: RGIDARGME ARAMEARGLD ARGLEARAME ARAMEARAME ARAMEARAME VRGMEARGMD TRGPVPGPRG PIPSGMQGPS PINMGAVVPQ GSRQVPVM (408-504 aa encoded by BC017712)
CSTF2 is one of three (including CSTF1 and CSTF3) cleavage stimulation factors which combine to form CSTF which is involved in the polyadenylation and 3'end cleavage of pre-mRNAs. CSTF2 contains a ribonucleoprotein-type RNA binding domain. CSTF2 is upregulated during activation of B cells which results in the switch of IgM heavy chain mRNA from membrane bound form to the secreted form.
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Protein Aliases: alphaCstF-64 variant 4; betaCstF-64 variant 1; betaCstF-64 variant 2; betaCstF-64 variant 3; CF-1 64 kDa subunit; Cleavage stimulation factor 64 kDa subunit; Cleavage stimulation factor subunit 2; cleavage stimulation factor, 3' pre-RNA subunit 2, 64 kDa; cleavage stimulation factor, 3' pre-RNA, subunit 2; cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kD; cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa; CstF 64; CSTF 64 kDa subunit
Gene Aliases: C630034J23Rik; CstF-64; CSTF2; Cstf64; mir-3112
Molecular Function: mRNA polyadenylation factor