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Invitrogen

CtBP1 Polyclonal Antibody

View all (25) CtBP1 antibodies

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Product Details

PA5-29264

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:3,000
-

Immunocytochemistry (ICC/IF)

1:100-1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse, Zebrafish

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein encompassing a sequence within the center region of human CtBP1. The exact sequence is proprietary.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.69 mg/mL

Amount

69 µg

Purification

Antigen affinity chromatography

Storage buffer

0.1M tris glycine, pH 7, with 10% glycerol

Contains

0.01% thimerosal

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2546740

Product Specific Information

Recommended positive controls: Mouse brain.

Predicted reactivity: Mouse (98%), Rat (98%), Zebrafish (88%), Xenopus laevis (96%), Chicken (96%), Rhesus Monkey (99%).

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

This gene encodes a protein that binds to the C-terminus of adenovirus E1A proteins. This phosphoprotein is a transcriptional repressor and may play a role during cellular proliferation. This protein and the product of a second closely related gene, CTBP2, can dimerize. Both proteins can also interact with a polycomb group protein complex which participates in regulation of gene expression during development. Alternative splicing of transcripts from this gene results in multiple transcript variants.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: brefeldin A-ribosylated substrate; C-terminal-binding protein 1; CtBP1; MGC104684; transcriptional repressor

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Gene Aliases: BARS; CTBP; CTBP1; CtBP1-L; CtBP1-S; CtBP3/BARS; D4S115h; D5H4S115; D5H4S115E; HADDTS; wu:fi43a11

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UniProt ID: (Human) Q13363, (Mouse) O88712

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Entrez Gene ID: (Human) 1487, (Mouse) 13016, (Zebrafish) 65229

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Function(s)
transcription cofactor binding transcription corepressor binding chromatin binding transcription coactivator activity transcription corepressor activity protein binding oxidoreductase activity oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor protein domain specific binding identical protein binding NAD binding RNA polymerase II sequence-specific DNA binding transcription factor binding lncRNA binding DNA-binding transcription factor binding C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity RNA polymerase II transcription corepressor activity transcription factor activity, sequence-specific DNA binding aldo-keto reductase (NADP) activity isocitrate dehydrogenase activity mevaldate reductase activity transcription factor binding gluconate dehydrogenase activity steroid dehydrogenase activity epoxide dehydrogenase activity 5-exo-hydroxycamphor dehydrogenase activity 2-hydroxytetrahydrofuran dehydrogenase activity acetoin dehydrogenase activity phenylcoumaran benzylic ether reductase activity D-xylose:NADP reductase activity L-arabinose:NADP reductase activity D-arabinitol dehydrogenase, D-ribulose forming (NADP+) activity steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor steroid dehydrogenase activity, acting on the CH-CH group of donors (R)-(-)-1,2,3,4-tetrahydronaphthol dehydrogenase activity 3-hydroxymenthone dehydrogenase activity very long-chain-3-hydroxyacyl-CoA dehydrogenase activity dihydrotestosterone 17-beta-dehydrogenase activity protein homodimerization activity (R)-2-hydroxyisocaproate dehydrogenase activity L-arabinose 1-dehydrogenase (NADP+) activity L-xylulose reductase (NAD+) activity 3-ketoglucose-reductase activity (R)-2-hydroxyglutarate dehydrogenase activity D-arabinitol dehydrogenase, D-xylulose forming (NADP+) activity repressing transcription factor binding transcription cofactor
Process(es)
negative regulation of transcription from RNA polymerase II promoter regulation of transcription from RNA polymerase II promoter protein phosphorylation Notch signaling pathway negative regulation of cell proliferation viral genome replication cell differentiation negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated synaptic vesicle endocytosis white fat cell differentiation regulation of cell cycle synaptic vesicle clustering transcription, DNA-templated regulation of transcription, DNA-templated transcription from RNA polymerase II promoter metabolic process positive regulation of histone deacetylation negative regulation of histone acetylation oxidation-reduction process negative regulation of histone H4 acetylation negative regulation of transcription from RNA polymerase II promoter by histone modification retinoic acid receptor signaling pathway
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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