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CtIP Polyclonal Antibody
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Product Details
BS-6137R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human CtIP/RBBP8, amino acids 621-720.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
CtIP, a 125 kD protein, was originally found interacting with a transcription repressor, CtBP, through the PLDLS motif (CtBP-Interacting Protein) thus suggested a role in transcription. Studies have shown that CtIP also interacts with BRCA1 protein through the c-terminus BRCT domains also suggested that CtIP is a potential tumor suppressor. This CtIP-BRCA1 interaction can be disrupted by DNA damaging agents including UV or gamma-irradiation. Li et al (Nature 406, 210 - 215 (2000)) have shown that ATM phosphorylates CtIP at serine residues 664 and 745, and mutation of these sites abrogates the dissociation of BRCA1 from CtIP, resulting in persistent repression of BRCA1-dependent induction of GADD45 upon ionizing radiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CTBP-interacting protein; CtIP; DNA endonuclease RBBP8; RBBP-8; retinoblastoma binding protein 8; Retinoblastoma-binding protein 8; Retinoblastoma-interacting protein and myosin-like; RIM; RIM; retinoblastoma-interacting myosin like protein; SAE2; Sporulation in the absence of SPO11 protein 2 homolog; unnamed protein product
Gene Aliases: 9930104E21Rik; COM1; CTIP; JAWAD; JWDS; RBBP-8; RBBP8; RGD1308872; RIM; SAE2; SCKL2
UniProt ID: (Human) Q99708, (Rat) B1WC58, (Mouse) Q80YR6
Entrez Gene ID: (Human) 5932, (Rat) 291787, (Mouse) 225182
single-stranded DNA endodeoxyribonuclease activity
DNA binding
damaged DNA binding
transcription corepressor activity
nuclease activity
endonuclease activity
protein binding
hydrolase activity
identical protein binding
metal ion binding
RNA polymerase II sequence-specific DNA binding transcription factor binding
RNA polymerase II repressing transcription factor binding
RNA polymerase II transcription corepressor activity
molecular_function
phosphoric ester hydrolase activity
T/G mismatch-specific endonuclease activity
retroviral 3' processing activity
transcription cofactor
gene-specific transcriptional regulator
G1/S transition of mitotic cell cycle
double-strand break repair via homologous recombination
blastocyst hatching
DNA repair
cellular response to DNA damage stimulus
DNA double-strand break processing involved in repair via single-strand annealing
reciprocal DNA recombination
mitotic G2/M transition checkpoint
negative regulation of transcription, DNA-templated
cell division
meiotic cell cycle
DNA strand resection involved in replication fork processing
negative regulation of transcription from RNA polymerase II promoter
DNA catabolic process, endonucleolytic
mitotic nuclear division
response to estradiol
DNA damage checkpoint
nucleotide-excision repair
transcription from RNA polymerase II promoter
cell cycle
G2 DNA damage checkpoint
nucleic acid phosphodiester bond hydrolysis
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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