Invitrogen

Cullin 4A Polyclonal Antibody

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Cullin 4A Antibody in Western Blot (WB) — Western Blot analysis of Cullin 4A in extracts of various cell lines using Cullin 4A Polyclonal Antibody (Product # PA5-96216) at a dilution of 1:1000. A HRP Goat Anti-Rabbit IgG (H+L) secondary antibody was used at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST.

Product Details

PA5-96216

Applications	Tested Dilution	Publications
Western Blot (WB)	1:500-1:2,000	-
Immunocytochemistry (ICC/IF)	1:50-1:100	-
Immunoprecipitation (IP)	1:50-1:200	-

Product Specifications
Species Reactivity	Human, Mouse, Rat
Host/Isotype	Rabbit / IgG
Class	Polyclonal
Type	Antibody
Immunogen	A synthetic peptide corresponding to amino acids 200-300 of human Cullin 4A. View immunogen
Conjugate	Unconjugated
Form	Liquid
Concentration	0.43 mg/mL
Purification	Affinity Chromatography
Storage buffer	PBS, pH 7.3, with 50% glycerol
Contains	0.05% ProClin 300
Storage conditions	-20° C, Avoid Freeze/Thaw Cycles
RRID	AB_2808018

Product Specific Information

Positive Samples: K-562, BT-474, HeLa, Mouse testis

Target Information

CUL4A (Cullin 4A) is the ubiquitin ligase component of a multimeric complex involved in the degradation of DNA damage-response proteins.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: CUL 4A; CUL-4A; Cul4a protein; Cullin-4A; MGC36573; MGC64071; OTTHUMP00000018753

Gene Aliases: 2810470J21Rik; AW495282; CUL4A; RGD1563853

UniProt ID: (Human) Q13619, (Mouse) Q3TCH7

Entrez Gene ID: (Human) 8451, (Mouse) 99375, (Rat) 361181

Molecular Function: ubiquitin-protein ligase

G1/S transition of mitotic cell cycle nucleotide-excision repair, DNA damage recognition nucleotide-excision repair, DNA duplex unwinding in utero embryonic development transcription-coupled nucleotide-excision repair nucleotide-excision repair, preincision complex stabilization nucleotide-excision repair, preincision complex assembly nucleotide-excision repair, DNA incision, 3'-to lesion nucleotide-excision repair, DNA incision, 5'-to lesion cellular response to DNA damage stimulus cell cycle arrest positive regulation of cell proliferation negative regulation of cell proliferation viral process hemopoiesis negative regulation of granulocyte differentiation nucleotide-excision repair, DNA incision somatic stem cell population maintenance DNA damage response, detection of DNA damage protein ubiquitination involved in ubiquitin-dependent protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process regulation of protein metabolic process global genome nucleotide-excision repair intrinsic apoptotic signaling pathway positive regulation of G1/S transition of mitotic cell cycle regulation of DNA damage checkpoint regulation of nucleotide-excision repair DNA repair ubiquitin-dependent protein catabolic process positive regulation of protein catabolic process

Process(es)

protein binding ubiquitin protein ligase binding ubiquitin protein ligase activity