Immunogen sequence: MMSQSSGSGD GNDDEATTSK DGGFSSPSPS AAAAAQEVRS ATDGNTSTTP PTSAKKRKLN SSSSSSSNSS NEREDFDSTS SSSSTPPLQP RDSASPSTSS FCLGVSVAAS SHVPIQKKLR FEDTLEFVGF DAKMAEESSS SSSSSSPTAA TSQQQQLKNK SILISSVASV HHANGLAKSS TTVSSFANSK PGSAKKLVIK; Positive Samples: Mouse liver, Mouse kidney; Cellular Location: Nucleus
This gene is a member of the cullin family. The encoded protein forms a complex that functions as an E3 ubiquitin ligase and catalyzes the polyubiquitination of specific protein substrates in the cell. The protein interacts with a ring finger protein, and is required for the proteolysis of several regulators of DNA replication including chromatin licensing and DNA replication factor 1 and cyclin E. Multiple transcript variants encoding different isoforms have been found for this gene.
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Protein Aliases: CUL-4B; cul4b; Cullin-4B
Gene Aliases: 2700050M05Rik; AA409770; CUL-4B; CUL4B; KIAA0695; mKIAA0695; MRXHF2; MRXS15; MRXSC; RGD1564494; SFM2