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Proteintech
Cullin 5 Polyclonal Antibody
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Product Details
31183-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Cullin 5 fusion protein Ag34620
Conjugate
Form
Liquid
Concentration
0.4 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: MATSNLLKNK GSLQFEDKWD FMRPIVLKLL RQESVTKQQW FDLFSDVHAV CLWDDKGPAK IHQALKEDIL EFIKQAQARV LSHQDDTALL KAYIVEWRKF FTQCDILPKP FCQLEITLMG KQGSNKKSNV EDSIVRKLML DTWNESIFSN IKNRLQDSAM KLVHAERLGE AFDSQLVIGV RESYVNLCSN PEDKLQIYRD NFEKAYLDST ERFYRTQAPS YLQQNGVQNY MKYADAKLKE EEKRALRYLE TRRECNSVEA LMECCVNALV TSFKETILAE CQGMIKRNET EKLHLMFSLM
Target Information
CUL5 is a core component of multiple SCF-like ECS (Elongin-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAk2. It seems to be involved poteosomal degradation of p53/TP53 stimulated by adenovirus E1B-55 kDa protein and may form a cell surface vasopressin receptor.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CUL-5; Cullin-5; Cullin-5 (vasopressin-activated calcium-mobilizing receptor-1); VACM-1; Vasopressin-activated calcium-mobilizing receptor 1; vasopressin-activated calcium-mobilizing receptor protein; Vasopressin-activated calcium-mobilizing receptor-1
Gene Aliases: 4921514I20Rik; 8430423K24Rik; AI852817; C030032G03Rik; C330021I08Rik; CUL5; VACM-1; VACM1
UniProt ID: (Human) Q93034, (Rat) Q9JJ31, (Mouse) Q9D5V5
Entrez Gene ID: (Human) 8065, (Rat) 64624, (Mouse) 75717
G1/S transition of mitotic cell cycle
cell cycle arrest
cell proliferation
negative regulation of cell proliferation
viral process
ERBB2 signaling pathway
protein ubiquitination involved in ubiquitin-dependent protein catabolic process
calcium ion transmembrane transport
intrinsic apoptotic signaling pathway
protein polyubiquitination
ubiquitin-dependent protein catabolic process
response to osmotic stress
G-protein coupled receptor signaling pathway
protein ubiquitination
cerebral cortex radially oriented cell migration
radial glia guided migration of Purkinje cell
regulation of cytosolic calcium ion concentration
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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