This Antibody was verified by Cell Treatment to ensure that the antibody binds to the antigen stated. View Details
PA5-34682 targets Cyclin A2 in ICC, IF, IHC (P), IP, and WB applications and shows reactivity with Human, Mouse, and Rat samples.
The PA5-34682 immunogen is recombinant protein fragment contains a sequence corresponding to a region within amino acids 1 and 190 of Cyclin A2.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. In contrast to cyclin A1, which is present only in germ cells, this cyclin is expressed in all tissues tested. This cyclin binds and activates CDC2 or CDK2 kinases, and thus promotes both cell cycle G1/S and G2/M transitions.
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Protein Aliases: CCN1; CCNA; Cyclin A; Cyclin A2 (Cyclin A); Cyclin-A; Cyclin-A2
Gene Aliases: AA408589; Ccn-1; CCN1; CCNA; CCNA2; Cyca; CycA2