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Cyclin B2 is a member of the cyclin family, specifically the B-type cyclins. The B-type cyclins, B1 and B2, associate with p34cdc2 and are essential components of the cell cycle regulatory machinery. B1 and B2 differ in their subcellular localization. Cyclin B1 co-localizes with microtubules, whereas cyclin B2 is primarily associated with the Golgi region. Cyclin B2 also binds to transforming growth factor beta RII and thus cyclin B2/cdc2 may play a key role in transforming growth factor beta-mediated cell cycle control.
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Protein Aliases: G2/mitotic-specific cyclin-B2
Gene Aliases: CCNB2; HsT17299
UniProt ID: (Human) O95067
Entrez Gene ID: (Human) 9133
Molecular Function:
enzyme modulator
kinase activator
kinase modulator
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