Proteintech

Cyclin D2 Polyclonal Antibody

Product Image Gallery

Cyclin D2 Antibody in Western Blot (WB) — NIH/3T3 cells were subjected to SDS PAGE followed by western blot with 10934-1-AP ( Cyclin D2 antibody at dilution of 1:600 incubated at room temperature for 1.5 hours.

Product Details

10934-1-AP

Applications	Tested Dilution	Publications
Western Blot (WB)	1:500-1:1,000	View 7 publications 7 publications
Immunohistochemistry (IHC)	-	View 5 publications 5 publications
Immunocytochemistry (ICC/IF)	-	View 1 publication 1 publication
Miscellaneous PubMed (Misc)	-	View 1 publication 1 publication

Product Specifications
Species Reactivity	Human, Mouse
Published species	Human, Mouse, Pig
Host/Isotype	Rabbit / IgG
Class	Polyclonal
Type	Antibody
Immunogen	Cyclin D2 Fusion Protein Ag1377 (1-289 aa encoded by BC010958) View antigen
Conjugate	Unconjugated
Form	Liquid
Concentration	0.3 mg/mL
Purification	Antigen affinity chromatography
Storage buffer	PBS, pH 7.3, with 50% glycerol
Contains	0.1% sodium azide
Storage conditions	-20°C

Product Specific Information

Immunogen sequence: MELLCHEVD PVRRAVRDRN LLRDDRVLQN LLTIEERYLP QCSYFKCVQK DIQPYMRRMV ATWMLEVCEE QKCEEEVFPL AMNYLDRFLA GVPTPKSHLQ LLGAVCMFLA SKLKETSPLT AEKLCIYTDN SIKPQELLEW ELVVLGKLKW NLAAVTPHDF IEHILRKLPQ QREKLSLIRK HAQTFIALCA TDFKFAMYPP SMIATGSVGA AICGLQQDEE VSSLTCDALT ELLAKITNTD VDCLKACQEQ IEAVLLNSLQ QYRQDQRDGS KSEDELDQAS TPTDVRDIDL (1-289 aa encoded by BC010958)

Target Information

Cyclin D2 is a G1 cyclin required for G1 phase progression and is a strong candidate for a proto-oncogene. Cyclin D2 can phosphorylate pRB when associated with cdk 4 and / or cdk 6.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

The Oncogenic Transcription Factor RUNX1/ETO Corrupts Cell Cycle Regulation to Drive Leukemic Transformation.

Cancer cell

Martinez-Soria N,McKenzie L,Draper J,Ptasinska A,Issa H,Potluri S,Blair HJ,Pickin A,Isa A,Chin PS,Tirtakusuma R,Coleman D,Nakjang S,Assi S,Forster V,Reza M,Law E,Berry P,Mueller D,Osborne C,Elder A,Bomken SN,Pal D,Allan JM,Veal GJ,Cockerill PN,Wichmann C,Vormoor J,Lacaud G,Bonifer C,Heidenreich O

Mon Oct 08 00:00:00 EDT 2018

Transcription factor MafB may play an important role in secondary hyperparathyroidism.

Kidney international

Morito N,Yoh K,Usui T,Oishi H,Ojima M,Fujita A,Koshida R,Shawki HH,Hamada M,Muratani M,Yamagata K,Takahashi S

Mon Jan 01 00:00:00 EST 2018

Folate deprivation induces cell cycle arrest at G0/G1 phase and apoptosis in hippocampal neuron cells through down-regulation of IGF-1 signaling pathway.

The international journal of biochemistry & cell biology

Yang Y,Li X,Sun Q,He B,Jia Y,Cai D,Zhao R

Sat Oct 01 00:00:00 EDT 2016

Maternal gestational betaine supplementation-mediated suppression of hepatic cyclin D2 and presenilin1 gene in newborn piglets is associated with epigenetic regulation of the STAT3-dependent pathway.

The Journal of nutritional biochemistry

Cai D,Yuan M,Jia Y,Liu H,Hu Y,Zhao R

Tue Dec 01 00:00:00 EST 2015

Tetrandrine induces G1/S cell cycle arrest through the ROS/Akt pathway in EOMA cells and inhibits angiogenesis in vivo.

International journal of oncology

Xiao W,Jiang Y,Men Q,Yuan L,Huang Z,Liu T,Li W,Liu X

Thu Jan 01 00:00:00 EST 2015

SOX2 controls tumour initiation and cancer stem-cell functions in squamous-cell carcinoma.

Nature

Boumahdi S,Driessens G,Lapouge G,Rorive S,Nassar D,Le Mercier M,Delatte B,Caauwe A,Lenglez S,Nkusi E,Brohée S,Salmon I,Dubois C,del Marmol V,Fuks F,Beck B,Blanpain C