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Proteintech
Cyclin E1 Polyclonal Antibody
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Product Details
11554-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Arthropod,
Human,
Mouse,
Rat,
Zebrafish
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Cyclin E1 Fusion Protein Ag2110 (111-410 aa encoded by BC035498)
Conjugate
Form
Liquid
Concentration
0.31 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: ANREEVWKI MLNKEKTYLR DQHFLEQHPL LQPKMRAILL DWLMEVCEVY KLHRETFYLA QDFFDRYMAT QENVVKTLLQ LIGISSLFIA AKLEEIYPPK LHQFAYVTDG ACSGDEILTM ELMIMKALKW RLSPLTIVSW LNVYMQVAYL NDLHEVLLPQ YPQQIFIQIA ELLDLCVLDV DCLEFPYGIL AASALYHFSS SELMQKVSGY QWCDIENCVK WMVPFAMVIR ETGSSKLKHF RGVADEDAHN IQTHRDSLDL LDKARAKKAM LSEQNRASPL PSGLLTPPQS GKKQSSGPEM A (111-410 aa encoded by BC035498)
Target Information
Cyclin E belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. Cyclin E forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB. Two alternatively spliced transcript variants of this gene, which encode distinct isoforms, have been described. Two additional splice variants were reported but detailed nucleotide sequence information is not yet available.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: cyclin Es; cyclin Et; E-S; G1/S-specific cyclin-E1
Gene Aliases: AW538188; CCNE; CCNE1; CycE1; pCCNE1
UniProt ID: (Human) P24864, (Mouse) Q61457
Entrez Gene ID: (Human) 898, (Mouse) 12447
G1/S transition of mitotic cell cycle
regulation of transcription involved in G1/S transition of mitotic cell cycle
antral ovarian follicle growth
liver development
DNA replication initiation
protein phosphorylation
response to purine-containing compound
Wnt signaling pathway
androgen receptor signaling pathway
organ regeneration
cellular response to nutrient
response to estradiol
response to progesterone
response to vitamin E
response to cytokine
response to drug
response to ethanol
positive regulation of cell differentiation
regulation of protein kinase activity
positive regulation of transcription, DNA-templated
cell division
response to corticosterone
response to methylmercury
regulation of cell cycle
cell cycle
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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