This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated. View Details
Immunogen sequence: YRQVSLTAVKQ RFEDKRYGEI SQEEVLSYSQ LCAALGVTQD SPDPPTFLST GEIHAFLSSP SGRRTKRKRE N
Highest antigen sequence identity to the following orthologs - mouse 78%, rat 82%.
This gene encodes a member of the cyclin family. Cyclins are important regulators of cell cycle transitions through their ability to bind and activate cyclin-dependent protein kinases. This member also belongs to the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and it was one of the first proteins in which the F-box motif was identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Cyclin-F; F-box only protein 1; FBX1; FBXO1; G2/mitotic-specific cyclin-F
Gene Aliases: CCNF; FBX1; FBXO1
UniProt ID: (Human) P41002
Entrez Gene ID: (Human) 899