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Proteintech
Cyclin H Polyclonal Antibody
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Product Details
10718-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Cyclin H Fusion Protein Ag1088 (1-323 aa encoded by BC005280)
Conjugate
Form
Liquid
Concentration
0.19 mg/mL
Amount
28.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MYHNSSQKR HWTFSSEEQL ARLRADANRK FRCKAVANGK VLPNDPVFLE PHEEMTLCKY YEKRLLEFCS VFKPAMPRSV VGTACMYFKR FYLNNSVMEY HPRIIMLTCA FLACKVDEFN VSSPQFVGNL RESPLGQEKA LEQILEYELL LIQQLNFHLI VHNPYRPFEG FLIDLKTRYP ILENPEILRK TADDFLNRIA LTDAYLLYTP SQIALTAILS SASRAGITME SYLSESLMLK ENRTCLSQLL DIMKSMRNLV KKYEPPRSEE VAVLKQKLER CHSAELALNV ITKKRKGYED DDYVSKKSKH EEEEWTDDDL VESL (1-323 aa encoded by BC005280)
Target Information
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with CDK7 kinase and ring finger protein MAT1. The kinase complex is able to phosphorylate CDK2 and CDC2 kinases, thus functions as a CDK-activating kinase (CAK). This cyclin and its kinase partner are components of TFIIH, as well as RNA polymerase II protein complexes. They participate in two different transcriptional regulation processes, suggesting an important link between basal transcription control and the cell cycle machinery.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CAK complex subunit; CCNH; CDK-activating kinase complex subunit; cyclin-dependent kinase-activating kinase complex subunit; Cyclin-H; MO15-associated protein; OTTHUMP00000222395; OTTHUMP00000222396; p34; p37; unnamed protein product
Gene Aliases: 6330408H09Rik; AI661354; AV102684; AW538719; CAK; CCNH; CycH; p34; p37
UniProt ID: (Human) P51946, (Mouse) Q61458, (Rat) Q9R1A0
Entrez Gene ID: (Human) 902, (Mouse) 66671, (Rat) 84389
protein binding
obsolete general RNA polymerase II transcription factor activity
kinase activity
cyclin-dependent protein serine/threonine kinase regulator activity
cyclin-dependent protein serine/threonine kinase activity
DNA-dependent ATPase activity
RNA polymerase II carboxy-terminal domain kinase activity
protein kinase binding
molecular_function
kinase activator
transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transcription initiation from RNA polymerase II promoter
protein stabilization
regulation of G1/S transition of mitotic cell cycle
regulation of cyclin-dependent protein serine/threonine kinase activity
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
protein phosphorylation
cell cycle
phosphorylation
positive regulation of transcription from RNA polymerase II promoter
regulation of cell cycle
biological_process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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