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Invitrogen
Cyclophilin F Polyclonal Antibody
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FIGURE: 1 / 1
Cyclophilin F Antibody (PA5-96237) in WB
Western blot analysis of Cyclophilin F in various lysates. Samples were incubated with Cyclophilin F Polyclonal antibody (Product # PA5-96237) using a dilution of 1:600, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 30s.
Product Details
PA5-96237
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 100-207 of human PPIF (NP_0057201)
Conjugate
Form
Liquid
Concentration
0.95 mg/mL
Amount
95 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive Samples: HepG2, B cells, Mouse kidney; Cellular Location: Mitochondrion matrix
Immunogen sequence: PSFMCQAGDF TNHNGTGGKS IYGSRFPDEN FTLKHVGPGV LSMANAGPNT NGSQFFICTI KTDWLDGKHV VFGHVKEGMD VVKKIESFGS KSGRTSKKIV ITDCGQLS
Target Information
The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein is part of the mitochondrial permeability transition pore in the inner mitochondrial membrane. Activation of this pore is thought to be involved in the induction of apoptotic and necrotic cell death.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: cyclophilin 3; Cyclophilin D; Cyclophilin F; CyP-D; CyP-M; Mitochondrial cyclophilin; mitochondrial Cyclophilin D; mitochondrial peptidyl-prolyl cis-trans isomerase; Peptidyl-prolyl cis-trans isomerase F; Peptidyl-prolyl cis-trans isomerase F, mitochondrial; peptidyl-prolyl cis-trans isomerase, mitochondrial; PPIase F; Rotamase F; unnamed protein product
Gene Aliases: AW457192; CyP-D; CyP-F; CyP-M; CYP3; CypD; PPIase; PPIF
UniProt ID: (Human) P30405, (Mouse) Q99KR7
Entrez Gene ID: (Human) 10105, (Mouse) 105675
response to ischemia
protein folding
apoptotic process
response to oxidative stress
mitochondrion organization
apoptotic mitochondrial changes
regulation of proton-transporting ATPase activity, rotational mechanism
programmed cell death
negative regulation of apoptotic process
regulation of mitochondrial membrane permeability
mitochondrial depolarization
muscle structure development
necroptotic process
cellular response to hydrogen peroxide
cellular response to arsenic-containing substance
cellular response to calcium ion
negative regulation of release of cytochrome c from mitochondria
negative regulation of oxidative phosphorylation
skeletal muscle fiber differentiation
regulation of mitochondrial membrane permeability involved in programmed necrotic cell death
mitochondrial outer membrane permeabilization involved in programmed cell death
negative regulation of intrinsic apoptotic signaling pathway
protein peptidyl-prolyl isomerization
regulation of necrotic cell death
negative regulation of ATPase activity
regulation of apoptotic process
positive regulation of release of cytochrome c from mitochondria
negative regulation of oxidative phosphorylation uncoupler activity
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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