Immunogen sequence: IPGGLSEAKP ATPEIQEIVD KVKPQLEEKT NETYGKLEAV QYKTQVVAGT NYYIKVRAGD NKYMHLKVFK SLPGQNEDLV
Highest antigen sequence identity to the following orthologs: Mouse - 60%, Rat - 65%.
The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins, and kininogens. This gene encodes a stefin that functions as a cysteine protease inhibitor, forming tight complexes with papain and the cathepsins B, H, and L. The protein is one of the precursor proteins of cornified cell envelope in keratinocytes and plays a role in epidermal development and maintenance. Stefins have been proposed as prognostic and diagnostic tools for cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: cystatin A (stefin A); cystatin AS; Cystatin-A; Cystatin-A, N-terminally processed; Cystatin-AS; Stefin-A; STF1; STFA
Gene Aliases: AREI; CSTA; PSS4; STF1; STFA
UniProt ID: (Human) P01040
Entrez Gene ID: (Human) 1475