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Cytochrome P450 Polyclonal Antibody

View all (13) CYP1A1 antibodies

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Product Details

600-401-HB7

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
-

Immunohistochemistry (IHC)

1:100-1:200
-

Immunocytochemistry (ICC/IF)

15 µg/mL
-

ELISA (ELISA)

5.0 µg/mL
-
Product Specifications

Species Reactivity

Human, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Anti-Cytochrome p450 antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to an internal portion of human cytochrome p450 conjugated to Keyhole Limpet Hemocyanin (KLH).

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Affinity chromatography

Storage buffer

0.02M potassium phosphate, pH 7.2, with 0.15M NaCl

Contains

0.01% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

This affinity purified antibody is directed against human cytochrome p450. Blast analysis the immunogen sequence shows 83.3% identity with mouse, rat, hamster, and monkey.

Target Information

This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: aryl hydrocarbon hydroxylase; CYP; CYP1A1; CYP1A1v; alternatively spliced; CYPIA1; cytochrome P-450 protein; cytochrome P-450-1; cytochrome P1-450; cytochrome P1-450, dioxin-inducible; Cytochrome P450 1A1; Cytochrome P450 form 6; cytochrome P450 subfamily I (aromatic compound-inducible) member A1 (C6 form c) (C6 form c); cytochrome P450, 1a1; cytochrome P450, family 1, subfamily A, polypeptide 1; cytochrome P450, subfamily I (aromatic compound-inducible), member A1 (C6, form c) (C6, form c); cytochrome P450, subfamily I (aromatic compound-inducible), polypeptide 1; Cytochrome P450-C; Cytochrome P450-P1; Cytochrome P450MT2; dioxin-inducible; flavoprotein-linked monooxygenase; functional drug metabolizing enzyme; Hydroperoxy icosatetraenoate dehydratase; microsomal monooxygenase; P450; P450 form 6; P450-P1; P450form6; P450MT2; unnamed protein product; xenobiotic monooxygenase

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Gene Aliases: AHH; AHRR; CP11; CYP1; Cyp1a-1; CYP1A1; Cyp45c; Cypc45c; CYPIA1; P-450MC; P1-450; P450-C; P450DX

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UniProt ID: (Human) P04798, (Rat) P00185

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Entrez Gene ID: (Human) 1543, (Rat) 24296

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Function(s)
catalytic activity monooxygenase activity iron ion binding protein binding arachidonic acid monooxygenase activity steroid hydroxylase activity oxidoreductase activity oxidoreductase activity, acting on diphenols and related substances as donors oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen flavonoid 3'-monooxygenase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen lyase activity oxygen binding enzyme binding heme binding Hsp70 protein binding demethylase activity metal ion binding Hsp90 protein binding vitamin D 24-hydroxylase activity estrogen 16-alpha-hydroxylase activity estrogen 2-hydroxylase activity long-chain fatty acid omega-hydroxylase activity hydroperoxy icosatetraenoate dehydratase activity long-chain fatty acid omega-1 hydroxylase activity aromatase activity
Process(es)
response to hypoxia long-chain fatty acid metabolic process liver development lipid hydroxylation lipid metabolic process fatty acid metabolic process steroid biosynthetic process steroid catabolic process porphyrin-containing compound metabolic process xenobiotic metabolic process steroid metabolic process estrogen metabolic process amine metabolic process toxin metabolic process response to xenobiotic stimulus response to nematode response to herbicide response to toxic substance ethylene metabolic process coumarin metabolic process flavonoid metabolic process response to iron(III) ion insecticide metabolic process dibenzo-p-dioxin metabolic process phenol-containing compound metabolic process dibenzo-p-dioxin catabolic process epoxygenase P450 pathway response to food response to lipopolysaccharide response to vitamin A response to genistein response to immobilization stress xenobiotic catabolic process vitamin D metabolic process hormone metabolic process retinol metabolic process long-chain fatty acid biosynthetic process 9-cis-retinoic acid biosynthetic process camera-type eye development nitric oxide metabolic process response to arsenic-containing substance digestive tract development tissue remodeling hydrogen peroxide biosynthetic process response to hyperoxia maternal process involved in parturition hepatocyte differentiation cellular response to copper ion omega-hydroxylase P450 pathway olefinic compound metabolic process positive regulation of G1/S transition of mitotic cell cycle response to diphenyl ether response to Aroclor 1254 response to 2,3,7,8-tetrachlorodibenzodioxine response to 3-methylcholanthrene aging cell proliferation response to wounding response to virus embryo development ending in birth or egg hatching response to organic substance response to organic cyclic compound drug metabolic process developmental process response to drug heterocycle metabolic process response to antibiotic oxidation-reduction process demethylation cellular response to organic cyclic compound
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