Invitrogen

Cytochrome P450 Pan Polyclonal Antibody

View all (4) Cytochrome P450 Pan antibodies
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Datasheet
Protocols
Questions & Answers
Tech Support

Product Details

PA5-36232

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:50-1:200
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide corresponding to amino acids 100-150 of human CYP2C8
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2553427

Product Specific Information

This antibody detects endogenous protein at a molecular weight of 60 kDa.

Purity is >95% by SDS-PAGE.

Target Information

CYP2C9 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. CYP2C9 localizes to the endoplasmic reticulum and its expression is induced by rifampin. The enzyme is known to metabolize many xenobiotics, including phenytoin, tolbutamide, ibuprofen and S-warfarin.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: (R)-limonene 6-monooxygenase; (S)-limonene 6-monooxygenase; (S)-limonene 7-monooxygenase; (S)-mephenytoin hydroxylase associated cytochrome P450; 4-nitrophenol 2-hydroxylase; Cholesterol 25-hydroxylase; CYPIIC17; CYPIIC18; CYPIIC19; CYPIIC8; CYPIIC9; CYPIIE1; cytochrome P-450 II C; cytochrome P-450 S-mephenytoin 4-hydroxylase; Cytochrome P-450MP; Cytochrome P450 2C18; Cytochrome P450 2C19; Cytochrome P450 2C8; Cytochrome P450 2C9; Cytochrome P450 2E1; Cytochrome P450 form 1; Cytochrome P450 IIC2; Cytochrome P450 MP-12; Cytochrome P450 MP-20; Cytochrome P450 MP-4; Cytochrome P450 MP-8; Cytochrome P450 PB-1; cytochrome P450 subfamily 2e1 (ethanol-inducible); cytochrome P450, 2e1, ethanol inducible; cytochrome P450, family 2, subfamily C, polypeptide 18; cytochrome P450, family 2, subfamily C, polypeptide 19; cytochrome P450, family 2, subfamily C, polypeptide 8; cytochrome P450, family 2, subfamily C, polypeptide 9; cytochrome P450, family 2, subfamily E, polypeptide 1; cytochrome P450, subfamily 2E, polypeptide 1; cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 17; cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 18; cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 19; cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 8; cytochrome P450, subfamily IIE (ethanol-inducible), polypeptide 1; Cytochrome P450-11A; Cytochrome P450-254C; Cytochrome P450-6b/29c; Cytochrome P450-ALC; Cytochrome P450-J; Cytochrome P450RLM6; Fenbendazole monooxygenase (4'-hydroxylating); flavoprotein-linked monooxygenase; mephenytoin 4'-hydroxylase; Mephenytoin 4-hydroxylase; microsomal monooxygenase; P450 form 1; P450-J; P450RLM6; S-mephenytoin 4-hydroxylase; unspecific monooxygenase; xenobiotic monooxygenase

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Gene Aliases: CPC8; CPC9; CPCI; CPCJ; CPE1; CYP2C; CYP2C10; CYP2C17; CYP2C18; CYP2C19; CYP2C8; CYP2C9; CYP2E; Cyp2e-1; CYP2E1; CYPIIC17; CYPIIC19; CYPIIC8; CYPIIC9; MP-12/MP-20; P450-6B/29C; P450-J; P450C2C; P450C2E; P450IIC17; P450IIC19; P450IIC9

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UniProt ID: (Human) P33260, (Human) P33261, (Human) P10632, (Human) P11712, (Human) P05181, (Mouse) Q05421, (Rat) P05182

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Entrez Gene ID: (Human) 1562, (Human) 1557, (Human) 1558, (Human) 1559, (Human) 1571, (Mouse) 13106, (Rat) 25086

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Function(s)
monooxygenase activity iron ion binding arachidonic acid epoxygenase activity steroid hydroxylase activity oxygen binding heme binding aromatase activity oxidoreductase activity (S)-limonene 6-monooxygenase activity (S)-limonene 7-monooxygenase activity enzyme binding (R)-limonene 6-monooxygenase activity caffeine oxidase activity cholesterol 25-hydroxylase activity drug binding oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen 3-(3-hydroxyphenyl)propionate hydroxylase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 4-chlorobenzaldehyde oxidase activity 3,5-xylenol methylhydroxylase activity phenylacetate hydroxylase activity 4-nitrophenol 4-monooxygenase activity dimethyl sulfide monooxygenase activity alpha-pinene monooxygenase [NADH] activity phenanthrene 9,10-monooxygenase activity 1-hydroxy-2-naphthoate hydroxylase activity toluene 4-monooxygenase activity xylene monooxygenase activity dibenzothiophene monooxygenase activity 6-hydroxy-3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity chlorophenol 4-monooxygenase activity carbon disulfide oxygenase activity toluene 2-monooxygenase activity 1-hydroxy-2-oxolimonene 1,2-monooxygenase activity phenanthrene 1,2-monooxygenase activity tetrahydrofuran hydroxylase activity styrene monooxygenase activity toluene-4-sulfonate monooxygenase activity toluene-sulfonate methyl-monooxygenase activity 3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity 2-hydroxy-phenylacetate hydroxylase activity 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA 1,2-monooxygenase activity phenanthrene 3,4-monooxygenase activity toluene 3-monooxygenase activity 4-hydroxyphenylacetate,NADH:oxygen oxidoreductase (3-hydroxylating) activity limonene monooxygenase activity 2-methylnaphthalene hydroxylase activity 1-methylnaphthalene hydroxylase activity bisphenol A hydroxylase A activity salicylate 5-hydroxylase activity isobutylamine N-hydroxylase activity branched-chain dodecylbenzene sulfonate monooxygenase activity 3-HSA hydroxylase activity 4-hydroxypyridine-3-hydroxylase activity 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase activity 6-hydroxynicotinate 3-monooxygenase activity metal ion binding tocotrienol omega-hydroxylase activity thalianol hydroxylase activity FMN binding oxidoreductase oxygenase metabolite interconversion enzyme
Process(es)
xenobiotic metabolic process epoxygenase P450 pathway oxidation-reduction process steroid metabolic process monoterpenoid metabolic process drug metabolic process exogenous drug catabolic process heterocycle metabolic process omega-hydroxylase P450 pathway organic acid metabolic process oxidative demethylation urea metabolic process monocarboxylic acid metabolic process drug catabolic process cellular amide metabolic process triglyceride metabolic process response to ozone response to organonitrogen compound carbon tetrachloride metabolic process benzene metabolic process halogenated hydrocarbon metabolic process response to drug response to ethanol
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