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Invitrogen
D4 Dopamine Receptor Polyclonal Antibody
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FIGURE: 1 / 2
D4 Dopamine Receptor Antibody (PA5-89196) in IHC (P)
Immunohistochemistry analysis of D4 Dopamine Receptor in paraffin-embedded rat retina. Samples were incubated with D4 Dopamine Receptor Polyclonal antibody (Product # PA5-89196) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
Product Details
PA5-89196
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic Peptide
Conjugate
Form
Liquid
Concentration
1.27 mg/mL
Amount
127 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: AWLLSPRLCD ALMAMDVMLC TASIFNLCAI SVDRFVAVAV PLRYNRQGGS RRQLLLIGAT WLLSAAVAAP VLCGLNDVRG RDPAVCRLED RDYVVYSSVC S; Positive Samples: Mouse brain, Rat brain; Cellular Location: Cell membrane, Multi-pass membrane protein
Target Information
This gene encodes the D4 subtype of the dopamine receptor. The D4 subtype is a G-protein coupled receptor which inhibits adenylyl cyclase. It is a target for drugs which treat schizophrenia and Parkinson disease. Mutations in this gene have been associated with various behavioral phenotypes, including autonomic nervous system dysfunction, attention deficit/hyperactivity disorder, and the personality trait of novelty seeking. This gene contains a polymorphic number (2-10 copies) of tandem 48 nt repeats; the sequence shown contains four repeats.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: D(2C) dopamine receptor; D(4) dopamine receptor; Dopamine 4 receptor; Dopamine D4 receptor; dopamine receptor 4
Gene Aliases: AW125663; D4R; D4RA; Drd-4; Drd4
UniProt ID: (Mouse) P51436
Entrez Gene ID: (Rat) 25432, (Mouse) 13491
dopamine neurotransmitter receptor activity, coupled via Gi/Go
dopamine neurotransmitter receptor activity
protein binding
drug binding
SH3 domain binding
dopamine binding
identical protein binding
signal transducer activity
G-protein coupled receptor activity
G-protein coupled amine receptor activity
G-protein coupled receptor
activation of MAPK activity
behavioral fear response
synaptic transmission, dopaminergic
response to amphetamine
negative regulation of adenylate cyclase activity
adenylate cyclase-inhibiting dopamine receptor signaling pathway
dopamine receptor signaling pathway
short-term memory
circadian rhythm
locomotory behavior
associative learning
adult locomotory behavior
olfactory learning
photoperiodism
negative regulation of cAMP biosynthetic process
positive regulation of sodium:proton antiporter activity
positive regulation of kinase activity
response to histamine
regulation of dopamine metabolic process
fear response
regulation of circadian rhythm
regulation of neurotransmitter secretion
behavioral response to cocaine
response to steroid hormone
arachidonic acid secretion
negative regulation of protein secretion
modulation of synaptic transmission
regulation of calcium-mediated signaling
retina development in camera-type eye
inhibitory postsynaptic potential
positive regulation of penile erection
negative regulation of voltage-gated calcium channel activity
positive regulation of excitatory postsynaptic potential
signal transduction
G-protein coupled receptor signaling pathway
chemical synaptic transmission
sensory perception of chemical stimulus
rhythmic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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