The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
The laminar organization of multiple neuronal types in the cerebral cortex is required for normal cognitive function. In mice, the disabled-1 gene plays a central role in brain development, directing the migration of cortical neurons past previously formed neurons to reach their proper layer. This gene is similar to disabled-1, and the protein encoded by this gene is thought to be a signal transducer that interacts with protein kinase pathways to regulate neuronal positioning in the developing brain. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined.
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Protein Aliases: Dab reelin signal transducer 1; Dab, reelin signal transducer, homolog 1; Disabled homolog 1; RP23-356E21.1; yotari
Gene Aliases: AI956902; C630028C02Rik; DAB1; scm; scr; scrambler; yot
Molecular Function: scaffold/adaptor protein