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Proteintech

DAB2 Polyclonal Antibody, CoraLite® Plus 488

View all (15) DAB2 antibodies

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Product Details

CL488-10109

Applications
Tested Dilution
Publications

Immunocytochemistry (ICC/IF)

1:50-1:500
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

DAB2 fusion protein Ag0162

Conjugate

CoraLite® Plus 488 CoraLite® Plus 488 CoraLite® Plus 488

Excitation/Emission Max

493/522 nm

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol, 0.5% BSA

Contains

0.05% ProClin 300

Storage conditions

-20°C, store in dark

Shipping conditions

Wet ice

Product Specific Information

Immunogen sequence: VDYFGQQFD QISNRTGKQE AQAGPWPFSS SQTQPAVRTQ NGVSEREQNG FSVKSSPNPF VGSPPKGLSI QNGVKQDLES SVQSSPHDSI AIIPPPQSTK PGRGRRTAKS SANDLLASDI FAPPVSEPSG QASPTGQPTA LQPNPLDLFK TSAPAPVGPL VGLGGVTVTL PQAGPWNTAS LVFNQSPSMA PGAMMGGQPS GFSQPVIFGT SPAVSGWNQP SPFAASTPPP VPVVWGPSAS VA

Target Information

DAB2 mRNA is expressed in normal ovarian epithelial cells but is down-regulated or absent from ovarian carcinoma cell lines. The 770-amino acid predicted protein has an overall 83% identity with the mouse p96 protein, a putative mitogen-responsive phosphoprotein; homology is strongest in the amino-terminal end of the protein in a region corresponding to the phosphotyrosine interaction domain. The down-regulation of DAB2 may play an important role in ovarian carcinogenesis. This gene was initially named DOC2 (for Differentially expressed in Ovarian Cancer) and is distinct from the DOC2A and DOC2B genes (for double C2-like domains, alpha and beta).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Adaptor molecule disabled-2; Dab, mitogen-responsive phosphoprotein, homolog 2; DAB2, clathrin adaptor protein; Differentially expressed in ovarian carcinoma 2; Differentially-expressed protein 2; Disabled homolog 2; disabled homolog 2, mitogen-responsive phosphoprotein; DOC-2; FLJ26626; mitogen responsive phosphoprotein; unnamed protein product

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Gene Aliases: DAB2; DOC-2; DOC2

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UniProt ID: (Human) P98082

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Entrez Gene ID: (Human) 1601

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Function(s)
protein binding clathrin adaptor activity cargo receptor activity SMAD binding low-density lipoprotein particle receptor binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter endocytosis receptor-mediated endocytosis apoptotic process transforming growth factor beta receptor signaling pathway integrin-mediated signaling pathway positive regulation of epithelial to mesenchymal transition negative regulation of neuron projection development protein transport Wnt signaling pathway cell differentiation negative regulation of cell growth positive regulation of cell migration positive regulation of aldosterone biosynthetic process positive regulation of proteasomal ubiquitin-dependent protein catabolic process leading edge cell differentiation negative regulation of apoptotic process positive regulation of endocytosis positive regulation of transcription from RNA polymerase II promoter clathrin coat assembly response to steroid hormone negative regulation of epithelial cell proliferation positive regulation of SMAD protein import into nucleus negative regulation of androgen receptor signaling pathway negative regulation of ERK1 and ERK2 cascade cellular response to epidermal growth factor stimulus cellular response to transforming growth factor beta stimulus negative regulation of canonical Wnt signaling pathway positive regulation of substrate adhesion-dependent cell spreading response to salt negative regulation of protein localization to plasma membrane positive regulation of Wnt signaling pathway, planar cell polarity pathway positive regulation of clathrin-mediated endocytosis positive regulation of early endosome to late endosome transport positive regulation of aldosterone secretion
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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