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Invitrogen
DAB2 Polyclonal Antibody
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Product Details
PA5-49237
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide between 624-650 amino acids from the C-terminal region of mouse Dab2.
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein A, Antigen affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Predicted to react with rat based on sequence homology.
Target Information
DAB2 mRNA is expressed in normal ovarian epithelial cells but is down-regulated or absent from ovarian carcinoma cell lines. The 770-amino acid predicted protein has an overall 83% identity with the mouse p96 protein, a putative mitogen-responsive phosphoprotein; homology is strongest in the amino-terminal end of the protein in a region corresponding to the phosphotyrosine interaction domain. The down-regulation of DAB2 may play an important role in ovarian carcinogenesis. This gene was initially named DOC2 (for Differentially expressed in Ovarian Cancer) and is distinct from the DOC2A and DOC2B genes (for double C2-like domains, alpha and beta).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Adaptor molecule disabled-2; Differentially expressed in ovarian carcinoma 2; Disabled homolog 2; DOC-2; FLJ26626; Mitogen-responsive phosphoprotein
Gene Aliases: 5730435J12Rik; AA960054; AI957090; D15Wsu122e; D630005B22Rik; Dab2; Doc-2; Doc2; p96
UniProt ID: (Mouse) P98078
Entrez Gene ID: (Mouse) 13132
cell morphogenesis involved in differentiation
in utero embryonic development
positive regulation of receptor recycling
positive regulation of protein phosphorylation
transport
endocytosis
receptor-mediated endocytosis
pinocytosis
apoptotic process
activation of JUN kinase activity
multicellular organism development
endoderm development
excretion
positive regulation of epithelial to mesenchymal transition
positive regulation of pathway-restricted SMAD protein phosphorylation
negative regulation of neuron projection development
protein transport
Wnt signaling pathway
cell differentiation
negative regulation of cell growth
positive regulation of cell migration
positive regulation of transforming growth factor beta receptor signaling pathway
negative regulation of protein binding
positive regulation of aldosterone biosynthetic process
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
positive regulation of transcription elongation from RNA polymerase II promoter
leading edge cell differentiation
negative regulation of apoptotic process
positive regulation of cell adhesion
positive regulation of endocytosis
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
clathrin coat assembly
response to steroid hormone
negative regulation of epithelial cell proliferation
positive regulation of SMAD protein import into nucleus
negative regulation of androgen receptor signaling pathway
negative regulation of ERK1 and ERK2 cascade
cellular response to epidermal growth factor stimulus
cellular response to transforming growth factor beta stimulus
negative regulation of canonical Wnt signaling pathway
positive regulation of substrate adhesion-dependent cell spreading
negative regulation of protein localization to plasma membrane
positive regulation of Wnt signaling pathway, planar cell polarity pathway
regulation of Rho-dependent protein serine/threonine kinase activity
positive regulation of clathrin-mediated endocytosis
positive regulation of early endosome to late endosome transport
positive regulation of aldosterone secretion
positive regulation of integrin-mediated signaling pathway
negative regulation of extrinsic apoptotic signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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