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Invitrogen

DAB2IP Polyclonal Antibody

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DAB2IP Polyclonal Antibody

Product Details

PA5-144652

Applications
Tested Dilution
Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:800
-

Immunocytochemistry (ICC/IF)

1:200
-
Product Specifications

Species Reactivity

Human, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein within human DAB2IP aa 950-1189.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

2 mg/mL

Amount

200 µg

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4, with 0.1% BSA, 40% glycerol

Contains

0.05% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_3094045

Product Specific Information

Positive control: Mouse brain tissue lysate, rat brain tissue lysate, Hela cell lysate, A431 cell lysate, human thyroid carcinoma tissue, SH-SY5Y.

Predicted band size: 132 kDa

Subcellular Location: Cell membrane, Cytoplasm.

Target Information

DAB2IP is a Ras GTPase-activating protein (GAP) that acts as a tumor suppressor. The DAB2IP gene is inactivated by methylation in prostate and breast cancers.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: AIP-1; ASK-interacting protein 1; ASK1-interacting protein 1; DAB2 interaction protein; DAB2-interacting protein; DIP1/2; disabled homolog 2 interacting protein; Disabled homolog 2-interacting protein; DOC-2/DAB-2 interactive protein; DOC-2/DAB2 interactive protein; DOC2/DAB2 interactive protein; MLL fusion partner; nGAP-like protein; RasGAP; unnamed protein product

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Gene Aliases: AF9Q34; AIP-1; AIP1; DAB2IP; DIP1/2; KIAA1743

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UniProt ID: (Human) Q5VWQ8, (Rat) Q6P730

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Entrez Gene ID: (Human) 153090, (Rat) 192126

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Function(s)
GTPase activator activity death receptor binding protein binding SH3 domain binding kinase binding protein kinase binding mitogen-activated protein kinase kinase binding mitogen-activated protein kinase kinase kinase binding phosphatidylinositol-3-phosphate binding signaling adaptor activity Toll-like receptor 4 binding phosphatidylinositol 3-kinase regulatory subunit binding identical protein binding protein homodimerization activity vascular endothelial growth factor receptor 2 binding protein serine/threonine kinase activator activity phosphatidylinositol 3-kinase binding macromolecular complex binding cadherin binding protein phosphatase 2A binding phosphatidylinositol-4-phosphate binding 14-3-3 protein binding protein complex binding protein N-terminus binding GTPase-activating protein
Process(es)
negative regulation of transcription from RNA polymerase II promoter angiogenesis immune system process apoptotic process inflammatory response response to unfolded protein negative regulation of cell proliferation extrinsic apoptotic signaling pathway via death domain receptors negative regulation of endothelial cell migration negative regulation of epithelial cell migration negative regulation of epithelial to mesenchymal transition positive regulation of neuron projection development negative regulation of angiogenesis cell motility involved in cerebral cortex radial glia guided migration layer formation in cerebral cortex protein catabolic process negative regulation of vascular endothelial growth factor receptor signaling pathway positive regulation of protein complex assembly tumor necrosis factor-mediated signaling pathway negative regulation of toll-like receptor 4 signaling pathway negative regulation of GTPase activity cellular response to unfolded protein tube formation intracellular signal transduction cellular response to vascular endothelial growth factor stimulus vascular endothelial growth factor receptor-2 signaling pathway negative regulation of epidermal growth factor receptor signaling pathway negative regulation of protein catabolic process positive regulation of apoptotic process regulation of GTPase activity regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of I-kappaB kinase/NF-kappaB signaling negative regulation of I-kappaB kinase/NF-kappaB signaling regulation of protein complex assembly negative regulation of MAPK cascade positive regulation of MAPK cascade innate immune response positive regulation of protein catabolic process negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of JNK cascade negative regulation of Ras protein signal transduction negative regulation of fibroblast proliferation neuron projection morphogenesis negative regulation of epithelial cell proliferation regulation of cell cycle negative regulation of protein kinase B signaling intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress negative regulation of G0 to G1 transition negative regulation of ERK1 and ERK2 cascade cellular response to lipopolysaccharide cellular response to interleukin-1 cellular response to tumor necrosis factor cellular response to epidermal growth factor stimulus endothelial cell apoptotic process negative regulation of canonical Wnt signaling pathway positive regulation of synapse maturation lipid droplet formation positive regulation of dendrite development regulation of p38MAPK cascade negative regulation of vascular endothelial growth factor signaling pathway negative regulation of NIK/NF-kappaB signaling positive regulation of proteasomal protein catabolic process regulation of intracellular signal transduction positive regulation of IRE1-mediated unfolded protein response positive regulation of neuron migration positive regulation of apoptotic signaling pathway activation of MAPKKK activity negative regulation of protein phosphorylation I-kappaB phosphorylation activation of JUN kinase activity negative regulation of phosphatidylinositol 3-kinase signaling negative regulation of cell growth negative regulation of NF-kappaB transcription factor activity negative regulation of catenin import into nucleus reelin-mediated signaling pathway negative regulation of MAP kinase activity regulation of protein heterodimerization activity positive regulation of JUN kinase activity negative regulation of phosphatidylinositol 3-kinase activity cellular protein catabolic process positive regulation of epithelial cell proliferation positive regulation of cell cycle arrest negative regulation of protein serine/threonine kinase activity positive regulation of protein serine/threonine kinase activity negative regulation of cyclin catabolic process
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