Invitrogen

DAB2IP Polyclonal Antibody

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DAB2IP Polyclonal Antibody

Product Details

PA5-144652

Applications
Tested Dilution
Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:800
-

Immunocytochemistry (ICC/IF)

1:200
-
Product Specifications

Species Reactivity

Human, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein within human DAB2IP aa 950-1189/1189.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

2 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4, with 0.1% BSA, 40% glycerol

Contains

0.05% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_3094045

Product Specific Information

Positive control: Mouse brain tissue lysate, rat brain tissue lysate, Hela cell lysate, A431 cell lysate, human thyroid carcinoma tissue, SH-SY5Y.

Predicted band size: 132 kDa

Subcellular Location: Cell membrane, Cytoplasm.

Target Information

DAB2IP is a Ras GTPase-activating protein (GAP) that acts as a tumor suppressor. The DAB2IP gene is inactivated by methylation in prostate and breast cancers.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: AIP-1; ASK-interacting protein 1; ASK1-interacting protein 1; DAB2 interaction protein; DAB2-interacting protein; DIP1/2; disabled homolog 2 interacting protein; Disabled homolog 2-interacting protein; DOC-2/DAB-2 interactive protein; DOC-2/DAB2 interactive protein; DOC2/DAB2 interactive protein; nGAP-like protein

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Gene Aliases: AF9Q34; AIP-1; AIP1; DAB2IP; DIP1/2; KIAA1743

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UniProt ID: (Human) Q5VWQ8, (Rat) Q6P730

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Entrez Gene ID: (Human) 153090, (Rat) 192126

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Function(s)
GTPase activator activity death receptor binding protein binding SH3 domain binding kinase binding protein kinase binding mitogen-activated protein kinase kinase binding mitogen-activated protein kinase kinase kinase binding phosphatidylinositol-3-phosphate binding protein complex binding signaling adaptor activity Toll-like receptor 4 binding phosphatidylinositol 3-kinase regulatory subunit binding identical protein binding protein homodimerization activity vascular endothelial growth factor receptor 2 binding phosphatidylinositol 3-kinase binding protein phosphatase 2A binding phosphatidylinositol-4-phosphate binding 14-3-3 protein binding cadherin binding involved in cell-cell adhesion protein N-terminus binding GTPase-activating protein
Process(es)
negative regulation of transcription from RNA polymerase II promoter MAPK cascade activation of MAPKKK activity angiogenesis negative regulation of protein phosphorylation inflammatory response activation of signaling protein activity involved in unfolded protein response cell cycle I-kappaB phosphorylation activation of JUN kinase activity negative regulation of cell proliferation extrinsic apoptotic signaling pathway via death domain receptors negative regulation of endothelial cell migration negative regulation of epithelial cell migration negative regulation of epithelial to mesenchymal transition positive regulation of neuron projection development negative regulation of phosphatidylinositol 3-kinase signaling negative regulation of angiogenesis cell motility involved in cerebral cortex radial glia guided migration layer formation in cerebral cortex negative regulation of vascular endothelial growth factor receptor signaling pathway negative regulation of NF-kappaB transcription factor activity negative regulation of toll-like receptor 4 signaling pathway negative regulation of GTPase activity tube formation negative regulation of catenin import into nucleus cellular response to vascular endothelial growth factor stimulus vascular endothelial growth factor receptor-2 signaling pathway reelin-mediated signaling pathway regulation of growth negative regulation of epidermal growth factor receptor signaling pathway positive regulation of apoptotic process regulation of GTPase activity regulation of I-kappaB kinase/NF-kappaB signaling negative regulation of I-kappaB kinase/NF-kappaB signaling regulation of protein complex assembly negative regulation of MAP kinase activity positive regulation of MAPK cascade regulation of protein heterodimerization activity positive regulation of JUN kinase activity positive regulation of GTPase activity negative regulation of phosphatidylinositol 3-kinase activity cellular protein catabolic process innate immune response positive regulation of protein catabolic process negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of JNK cascade negative regulation of Ras protein signal transduction negative regulation of fibroblast proliferation neuron projection morphogenesis negative regulation of epithelial cell proliferation intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress negative regulation of G0 to G1 transition negative regulation of ERK1 and ERK2 cascade positive regulation of cell cycle arrest cellular response to lipopolysaccharide cellular response to interleukin-1 cellular response to tumor necrosis factor cellular response to epidermal growth factor stimulus negative regulation of protein serine/threonine kinase activity positive regulation of protein serine/threonine kinase activity endothelial cell apoptotic process negative regulation of canonical Wnt signaling pathway positive regulation of synapse maturation cell-cell adhesion positive regulation of dendrite development regulation of p38MAPK cascade negative regulation of vascular endothelial growth factor signaling pathway positive regulation of proteasomal protein catabolic process positive regulation of IRE1-mediated unfolded protein response negative regulation of cyclin catabolic process positive regulation of neuron migration positive regulation of apoptotic signaling pathway apoptotic process response to unfolded protein negative regulation of cell growth positive regulation of epithelial cell proliferation
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