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This gene is one of two genes which encode a protein similar to the Drosophila protein dachshund, a transcription factor involved in cell fate determination in the eye, limb and genital disc of the fly. The encoded protein contains two characteristic dachshund domains: an N-terminal domain responsible for DNA binding and a C-terminal domain responsible for protein-protein interactions. This gene is located on the X chromosome and is subject to inactivation by DNA methylation. The encoded protein may be involved in regulation of organogenesis and myogenesis, and may play a role in premature ovarian failure. Multiple transcript variants encoding different isoforms have been found for this gene.
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Protein Aliases: Dach2; Dachshund homolog 2; FLJ31391; MGC138545; RP11-345E19.1
Gene Aliases: DACH2
UniProt ID: (Human) Q96NX9
Entrez Gene ID: (Human) 117154
Molecular Function: winged helix/forkhead transcription factor