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Proteintech
DACT1 Polyclonal Antibody
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Product Details
27237-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
DACT1 fusion protein Ag26096
Conjugate
Form
Liquid
Concentration
0.4 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: VREKTRAGSK KCRFPDDLDT NKKLKKASSK GRKSGGGPEA GVPGRPAGGG HRAGSRAHGH GREAVVAKPK HKRTDYRRWK SSAEISYEEA LRRARRGRRE
Target Information
Dapper homolog 1, an ortholog of Xenopus Dpr, antagonizes Wnt signaling by promoting Dvl degradation via a lysosome inhibitor-sensitive and proteasome inhibitor-insensitive mechanism. Dapper homolog 1 acts as an interacting protein for Dvl, and the interaction is formed between the DEP (Dishevelled, Egl-10, and pleckstrin) domain of Dvl and the central and C-terminal regions of Dapper homolog 1. The gene for human Dapper homolog 1 is localized on chromosomal region 14q23.1. The protein impedes the degradation of CTNNB1/beta-catenin, thereby enhancing the transcriptional activation of target genes of the Wnt signaling pathway. The protein is also required for normal notochord formation and is downregulated in hepatocellular carcinomas (HCC). It is expressed in human liver and various other tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Dapper antagonist of catenin 1; Dapper homolog 1; dapper, antagonist of beta-catenin, homolog 1; dishevelled-binding antagonist of beta-catenin 1; hDPR1; Hepatocellular carcinoma novel gene 3 protein; heptacellular carcinoma novel gene 3
Gene Aliases: DACT1; DAPPER; DAPPER1; DPR1; FRODO; HDPR1; HNG3; THYEX3
UniProt ID: (Human) Q9NYF0
Entrez Gene ID: (Human) 51339
negative regulation of transcription from RNA polymerase II promoter
Wnt signaling pathway
neural tube development
positive regulation of Wnt signaling pathway
negative regulation of Wnt signaling pathway
regulation of protein stability
negative regulation of protein binding
positive regulation of protein binding
regulation of catenin import into nucleus
positive regulation of catenin import into nucleus
positive regulation of protein catabolic process
negative regulation of JNK cascade
embryonic hindgut morphogenesis
negative regulation of canonical Wnt signaling pathway
regulation of nodal signaling pathway
positive regulation of cellular protein catabolic process
negative regulation of beta-catenin-TCF complex assembly
regulation of Wnt signaling pathway, planar cell polarity pathway
negative regulation of G1/S transition of mitotic cell cycle
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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