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| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
1:1,000 | - |
Flow Cytometry (Flow) |
1:10-1:50 | View 1 publication 1 publication |
| Product Specifications | |
|---|---|
Species Reactivity |
Human, Mouse |
Published species |
Human |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
KLH conjugated synthetic peptide between 491-518 amino acids from the central region of human DAGLB |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
0.5 mg/mL |
Purification |
Protein A, Antigen affinity chromatography |
Storage buffer |
PBS |
Contains |
0.09% sodium azide |
Storage conditions |
-20° C, Avoid Freeze/Thaw Cycles |
RRID |
AB_2543831 |
Lipase that catalyzes the hydrolysis of arachidonic acid (AA)-esterified diacylglycerols (DAGs) to produce the principal endocannabinoid, 2-arachidonoylglycerol (2-AG) which can be further cleaved by downstream enzymes to release arachidonic acid (AA) for cyclooxygenase (COX)-mediated eicosanoid production (PubMed:14610053). Preferentially hydrolyzes DAGs at the sn-1 position in a calcium-dependent manner and has negligible activity against other lipids including monoacylglycerols and phospholipids (PubMed:14610053). Plays a key role in the regulation of 2-AG and AA pools utilized by COX1/2 to generate lipid mediators of macrophage and microglia inflammatory responses. Functions also as a polyunsaturated fatty acids-specific triacylglycerol lipase in macrophages. Plays an important role to support the metabolic and signaling demands of macrophages. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: DAGL-beta; DGL-beta; Diacylglycerol lipase-beta; KCCR13L; PUFA-specific triacylglycerol lipase; Sn1-specific diacylglycerol lipase beta
Gene Aliases: DAGLB; DAGLBETA; E330036I19Rik; KCCR13L
UniProt ID: (Human) Q8NCG7, (Mouse) Q91WC9
Entrez Gene ID: (Human) 221955, (Mouse) 231871
Molecular Function:
lipase
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