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Fabgennix
DAP Kinase 1 Polyclonal Antibody
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FIGURE: 1 / 1
DAP Kinase 1 Antibody (DAPK1-101AP) in IHC
Mouse Heart- DAP kinase 1 Primary Antibody: DAPK1-10AP; 1:50 dilution in IHC blocking buffer. DAB (Brown) staining and Hematoxylin QS (blue) counterstain. 40X magnification. FFPE section. 3111.Pb1.AP3111.Pb1.AP- MOUSE IHC Rat Heart- DAP kinase 1 Primary Antibody: DAPK1-10AP; 1:50 dilution in IHC blocking buffer. DAB (Brown) staining and Hematoxylin QS (blue) counterstain. 40X magnification. FFPE section. 31... View More
Product Details
DAPK1-101AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide taken within amino acid region 1370-1420 on human Death-associated protein kinase 1 protein.
Conjugate
Form
Liquid
Concentration
0.5-1.5 mg/mL
Purification
Affinity chromatography
Storage buffer
proprietary buffer, pH 7.4-7.8, with 30% glycerol, 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
DAPK1 is a large, calmodulin-dependent kinase involved in gamma-interferon induced programmed cell death and is a potential tumor suppressor. DAPK1 is involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and authophagy. It regulates both type I apoptotic and type II autophagic cell death signal, depending on the cellular setting. Type I apoptotic cell death is caspase-dependent, type II authophagic cell death is caspase-independent. DAPK1 phosphorylates PIN1 resulting in inhibition of its catalytic activity, nuclear localization, and cellular function. It also phosphorylates TPM1, STX1A, PRKD1, BECN1, TSC2, RPS6, MYL9, and DAPK3.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DAP kinase 1; Death-associated protein kinase 1; DKFZp781I035; OTTHUMP00000216193
Gene Aliases: D13Ucla1; DAP-Kinase; DAPK; DAPK1
UniProt ID: (Human) P53355, (Mouse) Q80YE7
Entrez Gene ID: (Human) 1612, (Rat) 306722, (Mouse) 69635
protein kinase activity
protein serine/threonine kinase activity
calmodulin-dependent protein kinase activity
protein binding
calmodulin binding
ATP binding
GTP binding
syntaxin-1 binding
identical protein binding
nucleotide binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
non-receptor serine/threonine protein kinase
protein phosphorylation
apoptotic process
extrinsic apoptotic signaling pathway via death domain receptors
regulation of autophagy
negative regulation of translation
intracellular signal transduction
regulation of apoptotic process
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
protein autophosphorylation
cellular response to interferon-gamma
apoptotic signaling pathway
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
regulation of N-methyl-D-aspartate selective glutamate receptor activity
negative regulation of apoptotic process
regulation of translation
signal transduction
phosphorylation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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