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Proteintech
DAPK1 Polyclonal Antibody
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Product Details
25136-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
DAPK1 Fusion Protein Ag18387 (1081-1410 aa encoded by BC113660)
Conjugate
Form
Liquid
Concentration
1.01 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: LLQILDAMD ICARDLSSGT MVDVPALIKT DNLHRSWADE EDEVMVYGGV RIVPVEHLTP FPCGIFHKVQ VNLCRWIHQQ STEGDADIRL WVNGCKLANR GAELLVLLVN HGQGIEVQVR GLETEKIKCC LLLDSVCSTI ENVMATTLPG LLTVKHYLSP QQLREHHEPV MIYQPRDFFR AQTLKETSLT NTMGGYKESF SSIMCFGCHD VYSQASLGMD IHASDLNLLT RRKLSRLLDP PDPLGKDWCL LAMNLGLPDL VAKYNTSNGA PKDFLPSPLH ALLREWTTYP ESTVGTLMSK LRELGRRDAA DFLLKASSVF KINLDGNGQE A (1081-1410 aa encoded by BC113660)
Target Information
DAPK1 is a large, calmodulin-dependent kinase involved in gamma-interferon induced programmed cell death and is a potential tumor suppressor. DAPK1 is involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and authophagy. It regulates both type I apoptotic and type II autophagic cell death signal, depending on the cellular setting. Type I apoptotic cell death is caspase-dependent, type II authophagic cell death is caspase-independent. DAPK1 phosphorylates PIN1 resulting in inhibition of its catalytic activity, nuclear localization, and cellular function. It also phosphorylates TPM1, STX1A, PRKD1, BECN1, TSC2, RPS6, MYL9, and DAPK3.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: DAP kinase 1; Death-associated protein kinase 1; DKFZp781I035; OTTHUMP00000216193
Gene Aliases: DAPK; DAPK1
UniProt ID: (Human) P53355
Entrez Gene ID: (Human) 1612
protein phosphorylation
apoptotic process
extrinsic apoptotic signaling pathway via death domain receptors
regulation of autophagy
negative regulation of translation
intracellular signal transduction
regulation of apoptotic process
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
protein autophosphorylation
cellular response to interferon-gamma
apoptotic signaling pathway
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
regulation of N-methyl-D-aspartate selective glutamate receptor activity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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