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Proteintech
DAPK3 Polyclonal Antibody
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Product Details
30656-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
DAPK3 fusion protein Ag33051
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
75 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: IRRLLVKDPK RRMTIAQSLE HSWIKAIRRR NVRGEDSGRK PERRRLKTTR LKEYTIKSHS SLPPNNSYAD FERFSKVLEE AAAAEEGLRE LQRSRRLCHE DVEALAAIYE
Target Information
DAPK3 is a serine/threonine kinase which is functionally linked to cell motility, smooth muscle contractility and cell death processes. DAPK3 is encoded by ZIPK and is a component of desmosomes and of the epidermal cornified envelope in keratinocytes. The N-terminal domain of this protein interacts with the plasma membrane and its C-terminus interacts with intermediate filaments. Through its rod domain, this protein forms complexes with envoplakin. This protein may serve as a link between the cornified envelope and desmosomes as well as intermediate filaments. AKT1/PKB, a protein kinase mediating a variety of cell growth and survival signaling processes, is reported to interact with this protein, suggesting a possible role for this protein as a localization signal in AKT1-mediated signaling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: DAP kinase 3; DAP-like kinase; DAP3K; Death-associated protein kinase 3; Dlk; MYPT1 kinase; unnamed protein product; ZIP kinase isoform; ZIP-kinase; Zipper-interacting protein kinase
Gene Aliases: DAPK3; DLK; ZIP; ZIPK
UniProt ID: (Human) O43293
Entrez Gene ID: (Human) 1613
nucleotide binding
protein kinase activity
protein serine/threonine kinase activity
protein binding
ATP binding
cAMP response element binding protein binding
kinase activity
transferase activity
small GTPase binding
identical protein binding
protein homodimerization activity
leucine zipper domain binding
protein serine kinase activity
chromatin organization
regulation of transcription, DNA-templated
regulation of translation
protein phosphorylation
apoptotic process
regulation of smooth muscle contraction
regulation of mitotic nuclear division
regulation of mitotic cell cycle
regulation of cell shape
regulation of autophagy
negative regulation of translation
positive regulation of cell migration
regulation of actin cytoskeleton organization
intracellular signal transduction
regulation of apoptotic process
positive regulation of apoptotic process
regulation of myosin II filament organization
protein autophosphorylation
regulation of focal adhesion assembly
cellular response to interferon-gamma
positive regulation of canonical Wnt signaling pathway
apoptotic signaling pathway
regulation of cell motility
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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